Pregnancy Flashcards
Pregnancy Diagnosis (4 ways)
Palpation
Ultrasonography
Radiology
Relaxin hormone testing
Palpation
Can be inconclusive
25 to 40 days after conception; gentle abdominal palpation of chorionic vesicles
40 days to term; general caudal abdominal distention but no distinct puppy bumps (cohesive enlargement)
50 days to term (late gestation) may actually palpate individual fetuses
Ultrasonography
Best to perform after day 25
Assess fetal viability by heart beat after day 25
Can be used to monitor problem pregnancy and embryonic fetal loss
Radiography
Requires skeletal mineralization
Day 45 to term
Radiographs
Order of puppy mineralization day 45
Mineralization of skull
Radiographs
Order of puppy mineralization day 48
Scapula
Humerus
Femur
Radiographs
Order of puppy mineralization day 52
Spinal column
Radius
Ulna
Tibia
Radiographs
Order of puppy mineralization day 54
Pelvis
Ribs
Radiographs
Order of puppy mineralization day 61
Coccygeal vertebrae Fibula Calcaneus Distal extremities Teeth
Hormones important during pregnancy
Progesterone Estrogen Relaxin Prolactin Growth Hormone
Progesterone during pregnancy
Elevated for duration of gestation
Maintains endometrial integrity
Attachment of placenta
Suppresses uterine contraction
Estrogen during pregnacy
Rises 10 to 15 days after LH surge
Supports progesterone secretion and progesterone receptors
Relaxin during pregnancy
Produced by placenta (by day 21-30)
Prolactin during pregnancy
Supports CL function
Growth Hormone during pregnancy
Increase leads to insulin resistance
Helps with mammary development
CBC/Chem Changes During Pregnancy
Normocytic, normochromic anemia
Mild neutrophilia Hypercholesterolemia Decreased TP Decreased BUN and Creatinine Insulin resistance Decreased serum Calcium
Weight
Conception greatest for females with BCS below ideal weight
Overweight females have increased problems during pregnancy and higher chance of dystocia
Nutrition Demand
Greatest during last 3 weeks of gestation and during lactation
Nutrition: What to feed
NRC and AAFCO approved diet formulated for all life stages
Carbohydrates, protein, fat at proper proportion
Vitamins, minerals, aa
Do NOT provide extra calcium supplementation during pregnancy; can/will cause Hypocalcemia (dogs do not draw Ca from diet but from Ca stores)
Nutrition: How much to feed
Feed the same as done prior to pregnancy and increase only at 3 weeks prior to whelping (when energy demand increases significantly)
Increase fed gradually over 7, 8, and 9 weeks to 50% pre-breeding intake
Lactation: increase fed up to 3 times the pre-breeding by third week of lactation
When is fetal growth rate the greatest?
Last 3 weeks of the pregnancy
Female will increase BW by 25% during this time
Pregnancy disorders relating to diet and energy (4)
Puerperal tetany/Eclampsia
Hypoglycemia
Pregnancy toxemia
Gestational diabetes mellitus
Puerperal Tetany/Eclampsia/Hypocalcemia
When?
What occurs?
Occurs most frequently at highest lactation
Loss of membrane bound calcium allows easier depolarization of muscle fibers
Puerperal Tetany/Eclampsia/Hypocalcemia
Clinical Signs
Uterine inertia Panting Whining Muscle fasciculations Seizures Hyperthermia
Puerperal Tetany/Eclampsia/Hypocalcemia
Bloodwork Abdnormalities
Hypocalcemia with normal albumin
Puerperal Tetany/Eclampsia/Hypocalcemia
Treatment
Acute: administer calcium slowly via IV
Monitor heart rate; stop injection with dysrhythmia
Oral supplementation with calcium carbonate and Vitamin D
Hypoglycemia
Uncommon
Clinical signs similar to puerperal tetany
Treat with IV dextrose
Check for glucosuria; R/O diabetes
Pregnancy Toxemia
Cause
Uncommon in dogs
Life threatening for pups and mom; may have to terminate pregnancy
Cause:
Large litter size and inadequate nutrition -> ketosis (must differentiate from diabetes mellitus)
Anorexia during the last 2-3 weeks of pregnancy
Gestational diabetes mellitus
How?
Progesterone stimulates growth hormone and leads to insulin resistance during late pregnancy
Could see DKA
Gestational diabetes mellitus
Diagnosis
High serum glucose or high urine glucose and urine ketones
Insulin therapy may help early in the disease
Drug administration consideration
Puppy effects
Pregnancy associated changes in serum albumin, CO, renal clearance
Class A Drug Type
Specific studies proven safe to use during pregnancy
Class B Drug Type
Laboratory animal studies show some risk, but likely safe if used cautiously
Class C Drug Type
Studies have shown potential risk and should be used only as last resort
Class D Drug Type
Contraindicated during pregnancy
Class A Antibiotics
Amoxicillin
Cephalosporin
Clavulanic acid
Clindamycin
Class A Antifungal
Miconazole
Class A Antiparasite
Fenbendazole
Pyrantel
Class A Anesthetic
Lidocaine
Naloxone
Class A Gastrointestinal
Antacids
Sucralfate
Class B Antibiotics
Sulfonamides
TMS
Class B Antifungal
Ketoconazole
Class B Anesthetic
Acepromazine Fentanyl Isoflurane Morphine Butorphenol
Class B Gastrointestinal
Antiemetics
Metoclopramide
Class B Cardiovascular
Dopamine
Heparin
Theophylline
Class C Antibiotics
Chloramphenicol
Gentamycin
Metronidazole
Class C Antiparasite
Amitraz
Class C Anesthetic
Diazepam
Halothane
Thiopental
Class C Endorine
Corticosteroids
Class D Antibiotics
Ciprofloxacin
Enrofloxacin
Tetracycline
Streptomycin
Class D Anesthetic
Pentobarbital
Class D Endocrine
Diethylstibestrol
Estradiol
Stanozolol
Testosterone