Pre-eclampsia Flashcards
What defines pre-eclampsia?
Hypertension and proteinuria
How frequently does pre-eclampsia occur?
5% of pregnancies
What causes pre-eclampsia?
Failure of trophoblastic invasion of spiral arteries leaving them vulnerable to vasoaconstrictors
When does pre-eclampsia resolve?
Within 6 weeks of delivery
What are the high risk factors for pre-eclampsia?
Previous severe or early-onset pre-eclampsia Chronic HTN HTN in previous pregnancy CKD Diabetes Mellitus Autoimmune disease
What are the moderate risk factors?
1st pregnancy >40yrs Pregnancy interval >10yrs BMI>30 FH pre-eclampsia Multiple pregnancy Low PAPPA Uterine artery notching
What intervention should be used to prevent pre-eclampsia if 1 high risk factors or 2 moderate risk factors?
Aspirin 75mg OD from 12th week until delivery
What fetal factors are risk factors for pre-eclampsia?
Hydatidiform mole
Multiple pregnancy
Fetal hydrops
What are the effects of pre-eclampsia?
Reduced plasma volume Increased peripheral volume Placental ischemia Micro aneurysms DIC Oedema (sudden) HELLP with placental infarcts
What are the severe complications of pre-eclampsia?
Eclampsia HELLP syndrome Cerebral haemorrhage IUGR Renal failure Placental abruption
Where can patients with pre-eclampsia deliver?
Labour ward only
What is mild pre-eclampsia?
140/149/90-99
Urine PCR >30
What is moderate pre-eclampsia?
150-159/100-109
What is severe pre-eclampsia?
> 160/110 or symptoms/signs of end organ damage
When should you start antihypertensives?
BP>150/100
