Pre-Cancer Dispositions Flashcards
Rare paraneoplastic indicator of visceral malignancy…
Acanthosis nigricans
Precursor to esophageal adenocarcinoma…
Barrett esophagus
Predispose to gastric carcinoma
Chronic Atrophic gastritis, post surgical gastric remnants
Predisposes to hepatocelular carcinoma
Cirrhosis
Precursor to squamous cell carcinoma of the skin…
Actinic keratosis
Precursor to visceral malignancy, particularly genitourinary…
Dermato- and polymyositis
Precursor to malignant melanoma…
Dysplastic nevus
This dermatologic condition predisposes to GI, breast, lung, and lymphoid malignancies…
Multiple seborrheic keratosis
Predisposes to 2* osteosarcoma and fibrosarcoma…
Paget disease of the bone
Predisposes to squamous cell carcinoma of the esophagus
Plummer-Vinson Syndrome
Often manifests with multiple hamartomas (benign) tumors including giant cell astrocytomas, renal angiomyolipomas, Cardiac Rhabdomyomas; tumors may become malignant.
Tuberous sclerosis
Predispose to squamous cell carcinoma, basal cell carcinoma, and melanoma…
Xeroderma pigmentosusm, Albinism
Predisposes to aggressive lymphoma (non-Hodgkin) and…
HIV
HIV also predisposes to Kaposi Sarcoma
Predispose to lymphoma
Autoimmune diseases like Hashimoto thyroiditis, SLE, Vitiligo… etc.
Down syndrome predisposes to what blood disorder?
Predisposes to acute lymphocytic leukemia
Predisposes to lymphoma, melanoma, renal cell carcinoma
Immunodeficiency
p53 mutation predisposes to various cancer types at a young age (e.g. Sarcoma, breast, leukemia, adrenal gland)
Li-Fraumeni Syndrome
High risk of developing leukemia, sarcoma, papillary thyroid cancer, breast cancer
Radiation exposure
Agent: 1,25-(OH)2 D3 (calcitriol) –> hypercalcemia… what is the associated neoplasm?
Hodgkin Lymphoma, non-Hodgkin Lymphoma
Agent: ACTH –> Cushing Syndrome… what is the associated neoplasm?
Small cell lung carcinoma, renal cell carcinoma
Agent: ADH –> SIADH… what is the associated neoplasm?
Small cell lung carcinoma, intracranial neoplasms
Agent: Antibodies against presynaptic Ca2+ channels at the NMJ –> Lambert Eaton myasthenic syndrome… what is the associated neoplasm?
Small cell lung carcinoma
Agent: Erythropoietin–> Polycythemia… what is the associated neoplasm?
Renal cell carcinoma, hemangioblastoma, hepatocellular carcinoma, leiomyoma, pheochromocytoma.
Agent: PTHrP –> Hypercalcemia… what is the associated neoplasm?
Squamous cell lung carcinoma, renal cell carcinoma, breast cancer
