Autoantibodies

Question 1

Autoantibody: Anti-Ach receptor

Answer 1

Myasthenia gravis

Question 2

Autoantibody: Anti-glomerular basement membrane

Answer 2

Goodpasture Syndrome

Question 3

Autoantibody: Anticardiolipin, ___ anticoagulant

Answer 3

SLE, antiphospholipid syndrome

Question 4

Autoantibody: Anticentromere

Answer 4

Limited scleroderma (Crest syndrome)

Question 5

Autoantibody: Anti-desmosome (anti-desmoglein)

Answer 5

Pemphigus Vulgaris

Question 6

Autoantibody: Anti-dsDNA, anti-Smith

Answer 6

SLE

Question 7

Anti-glutamic acid decarboxylase (GAD-65)

Answer 7

Type 1 Diabetes Mellitus

Autoantibody AKA: islet cell cytoplasmic antibodies

Question 8

Autoantibody: Antihemidesmosome

Answer 8

Bullous pemphigoid

Question 9

Autoantibody: Anti-histone

Answer 9

Drug-induced lupus

Question 10

Autoantibody: Anti-Jo-1, anti-SRP, anti-Mi-2

Answer 10

Polymyositis, dermatomyositis

Question 11

Autoantibody: Antimicrosomal, antithyroglobulin, antithyroid peroxidase

Answer 11

Hashimoto Thyroiditis

Question 12

Autoantibody: Antimitochondrial

Answer 12

Primary biliary cholangitis

Question 13

Autoantibody: Antinuclear antibodies (ANA)

Answer 13

Nonspecific screening antibody, often associated with SLE

Question 14

Autoantibody: Antiparietal cell, anti-intrinsic factor

Answer 14

Pernicious anemia

Question 15

Autoantibody: Anti-Scl-70 (anti-DNA topoisomerase I)

Answer 15

Scleroderma (diffuse)

Question 16

Anti-smooth muscle

Answer 16

Autoimmune hepatitis type 1

Question 17

Anti-SSA, anti-SSB (anti-Ro, anti-La)

Answer 17

Sjögren Syndrome

Question 18

Autoantibody: Anti-TSH receptor

Answer 18

Graves Disease

Question 19

Autoantibody: Anti-U1 RNP (ribonucleoprotein)

Answer 19

Mixed connective tissue disease

Question 20

Autoantibody: IgA anti-endomysial, IgA anti-tissue transglutaminase

Answer 20

Celiac disease

+ IgA and IgG deaminated gliadin peptide

Question 21

Autoantibody: MPO-ANCA/p-ANCA

Answer 21

Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome), Ulcerative Colitis

Question 22

Autoantibody: PR3-ANCA/c-ANCA

Answer 22

Granulomatosis with polyangiitis (Wegener)

Question 23

Autoantibody: anti-CCP (more specific)

Answer 23

Rheumatoid arthritis

Rheumatoid factor –> IgM antibody that targets IgG Fc region),

Question 24

Autoantibodies: Anti-phospholipase A2 receptor

Answer 24

Primary membranous nephropathy

Question 25

Antibodies: Anti-B2 (beta 2) glycoprotein

Answer 25

Antiphospholipid syndrome

Question 26

Antibodies: Anti-presynaptic voltage gated calcium channel

Answer 26

Lambert-Eaton myasthenic syndrome

Question 27

Autoantibody: Anti-IgG antibodies

Answer 27

Rheumatoid arthritis

Question 28

Autoantibody: Anti-citrullinated protein antibodies (ACPA)

Answer 28

Rheumatoid arthritis