Pathology- Inflammation

Question 0

What enzyme degrades bradykinin?

Answer 0

Angiotensin Converting Enzyme - ACE

Question 1

When the intrinsic pathway is inhibited, what other process is activated as well? What is the end product of that system?

Answer 1

Kininogen system –> end product is bradykinin

Question 2

A complication of ACE inhibitors is angioedema; it also inhibits the metabolism of bradykinin. What is a side effect of this?

Answer 2

Bradykinin causes an increase in vessel permeability (causing angioedema- swelling of the tissues) and an unexplainable cough. Bradykinin also causes pain along with PGE2.

Question 3

What factor do neutrophils and cancer cells share in order to cause basement membrane vascular permeability?

Answer 3

Type 4 collagenase (that’s how cancer cells metastasize)

Question 4

By what mechanism do neutrophils travel once they pass the basement membrane?

Answer 4

They get directions in a process called chemotaxis. C5a and LT-B4 (leukotriene B4) are chemotactic agents.