PRD class genes: mammal-specific expansion and early embryo development Flashcards
example of a class of genes which emerged from tandem gene duplication
ETCHbox genes
how did we figure out that ETCHbox genes emerged from gene duplication?
some of the genes are very close to Crx homeobox genes, and this is a pattern seen across placental mammals
useful techniques in determining gene function from RNAseq data
which genes are switched on by a specific gene? where is there overlap in targets?
GO analysis- looking at what the gene does and if you find any enrichments of particular functions
profile analysis- looks at if there are any patterns of gene expression which are enriched
DDC model
duplication degeneration complementation- gene duplication can sometimes lead to gain of function and retention of a gene, rather than the degradation we usually see
