Practice Questions Flashcards
Practice MCQs provided on canvas
Which of the following is the name of the first line of defence of the immune system?
a. Opportunistic immunity
b. Adaptive immunity
c. Innate immunity
d. Primary immunity
e. Central immunity
c. Innate immunity
Which of the following properties is common to macrophages and neutrophils in an
uninfected individual?
a. Life-span
b. Anatomical location
c. Ability to phagocytose
d. Morphology
e. Formation of pus
c. Ability to phagocytose
What term best describes C3a and C5a complement protein function?
a. Agglutinin
b. Anaphylatoxin
c. Cytokine
d. Opsonin
e. Membrane attack complex
b. Anaphylatoxin
What class of immunoglobulin has four subclasses and composes around 75% of the
immunoglobulin in serum?
a. IgA
b. IgD
c. IgE
d. IgG
e. IgM
d. IgG
What class of antibody is best at sensitizing mast cells?
a. IgA
b. IgD
c. IgE
d. IgG
e. IgM
c. IgE
The immunoglobulin heavy chain type first expressed during B cell development is?
a. IgM
b. IgG1
c. IgG2
d. IgA
e. IgD
a. IgM
How is diversity generated in the TCR?
a. Through affinity maturation
b. Through both affinity maturation and somatic hypermutation
c. Through combining different v gene segments with different peptides
d. Through combining different v gene segments with different j gene
e. Through somatic hypermutation
d. Through combining different v gene segments with different j gene
What is the structure of the MHC Class I complex on the surface of antigen
presenting cells?
a. A single protein chain associated with the beta-2-microglobulin protein.
b. A single protein chain associated with the beta-2-microglobulin protein and a short
peptide.
c. A single protein chain associated with the invariant chain protein
d. Two proteins chains associated with a short peptide
e. Two proteins chains associated with the CLIP peptide
b. A single protein chain associated with the beta-2-microglobulin protein and a short peptide
What are the proteasome subunits LMP2, LMP7 and MECL-1?
a. part of the constitutive proteasome
b. present in the 19S regulatory particle
c. involved in the MHC Class I and MHC Class II antigen presentation pathways
d. only involved in the MHC Class II pathway
e. incorporated into the proteasome after cells are treated with IFN-gamma
e. incorporated into the proteasome after cells are treated with IFN-gamma
The transcription factor FoxP3 is associated with which CD4+ T cell subtype?
a. Th1
b. Th2
c. Th17
d. Treg
e. Tfh
d. Treg
One of the main functions of IFN-alpha and -beta is:
a. to downregulate expression of MHC Class I molecules
b. to downregulate expression of MHC Class II molecules
c. to induce an antiviral state within uninfected cells
d. to help viruses replicate within cells
e. to change the proteolytic activity of the proteasome c
c. to induce an antiviral state within uninfected cells
Which of the following cytokines is most commonly associated with the inflammatory
response in innate immunity?
a. Interleukin-4 (IL-4)
b. Interferon-gamma (IFN-γ)
c. Tumour necrosis factor-alpha (TNF-α)
d. Interleukin-10 (IL-10)
e. Interleukin-2 (IL-2)
c. Tumour necrosis factor alpha (TNF-α)
Which of the following cells are phagocytes?
a. B cell
b. Epithelial cell
c. Dendritic cell
d. Macrophage
e. NK cell
d. Macrophage
Which type of hypersensitivity reaction is typically caused by T-lymphocytes?
a. Type I
b. Type II
c. Type III
d. Type IV
e. Type V
d. Type IV
Which one of the following statements is true?
a. IgE binds via its Fc region to Fc receptors on mast cells
b. Antigen binds to Fc receptors on mast cells
c. IgE binds to mast cell receptors after interaction with antigen
d. Binding of IgE to mast cell receptors induces cellular activation
e. Mast cells produce IgE
a. IgE binds via its Fc region to Fc receptors on mast cells
Which of the following is NOT typically associated with prevention of Autoimmune
disease
a. Thymic deletion of self-reactive T cells against ubiquitous antigen
b. Thymic deletion of self-reactive T cells against soluble antigen
c. Peripheral anergy of tissue-specific antigens
d. Activation of dendritic cells by gastrointestinal pathogens
e. Tregs prevent activation of any remaining self-reactive T cells
d. Activation of dendritic cells by gastrointestinal pathogens
Endosomal proteins important for the detection of viral nucleic acid?
a. Cathpesins
b. Toll-like receptors
c. IRF3
d. RIG-1
e. STAT4
b. Toll-like receptors
Which of the following receptors is involved in adaptive immunity?
a. Pattern-recognition receptor
b. Toll-like receptor
c. C-type lectin receptor
d. Nod-like receptor
e. T cell receptor
e. T cell receptor
Which statement is FALSE regarding MHC Class-I presentation and CTL responses
a. MHC Class-I antigen is only expressed on Antigen Presenting Cells (APC)
b. MHC Class-I antigen is expressed on all nucleated Cells
c. CTL epitopes are typically 8-9 amino acids in length
d. MHC Class-I binds to the CD8 molecule on T cells
e. CTL secrete perforin that lyse HIV-1 infected cells
a. MHC class-I antigen is only expressed on Antigen Presenting Cells (APC)
Depletion of which cell type causes a reduction in adult worm burden during
infection of mice with the filarial nematode Litomosoides sigmodontis?
a. Eosinophils
b. B-cells
c. Cytotoxic T-cells
d. Interstitial cells of Cajal
e. T-regs
e. Tregs
