Antigen recognition by T cells

Question 1

Immunologically naïve

Answer 1

Haven’t interacted with a foreign protein

Question 2

Key features of adaptive immune response

Answer 2

Diversity
Memory
Can discriminate self from non-self

Question 3

T cell : target interaction

Answer 3

T cell receptor interacts w MHC of antigen-presenting cell

Question 4

T cell receptors

Answer 4

T cell have receptors on their surface consisting of a single antigen binding site and transmembrane proteins.
Similar to antibody Fab region, but membrane bound and a slightly different structure

Question 5

How does recognition differ between TCRs and antibodies?

Answer 5

Antibodies recognise whole, folded proteins
TCRs recognise short segments from anywhere in the protein present in the MHC

Question 6

What happens when TCRs recognise antigens?

Answer 6

They DO NOT bind
Antigen is broken down and then bound to the MHC, not the receptor

Question 7

TCR structure components

Answer 7

Variable and constant regions
Heterodimer molecule
Glycoproteins
Linked by a disulphide bond
Transmembrane region
V short cytoplasmic tail

Question 8

Which MHC class do CD4+ recognise?

Answer 8

1

Question 9

Which MHC class do CD8+ recognise?

Answer 9

2