Practice Q

Question 1

What is local anaesthetics cellular mechanism of action?

Answer 1

Inhibits sodium getting into cell

Question 2

Some disadvantages of local anaesthetics?

Answer 2

Hypotension & arrhythmias

Question 3

Anaesthetics are usually fat soluble meaning they can..

Answer 3

Cross the blood brain barrier

Question 4

What are the disadvantages of Ketamine?

Answer 4

High BP

Question 5

What are the disadvantages f Thiopental?

Answer 5

Rapid awakening and long lasting sedation

Question 6

Cell Membrane

Answer 6

Likely target for a drug to act on

Question 7

Which drug binds to an enzyme to cause its actions?

Answer 7

Aspirin

Question 8

Agonist

Answer 8

Binds to a receptor and causes a response

Question 9

Glyceryl Trinitrate

Answer 9

Via spray
Via transdermal patch
Sublingually

Question 10

Consider the oral administration of drugs:

Answer 10

The drug should be largely lipid soluble

Question 11

Phase 1 Reactions:

Answer 11

Products can be more chemically active the parent drug

Question 12

If a patient has cirrhosis of the liver

Answer 12

The plasma half-life will increase

Question 13

Facilitated Diffusion:

Answer 13

Can become saturated

Question 14

Inhibitory Neurotransmitter in the brain

Answer 14

GABA

Gylcine

Question 15

Hypothroidism:

Answer 15

Can be caused by iodine deficiency

Question 16

Glucocorticoids

Answer 16

Must be withdrawn gradually

Question 17

Contraceptive Pill

Answer 17

Interacts with some hepatic enzyme inducers

Question 18

Fibrinolytic drugs

Answer 18

Are used to treat cardiovascular thrombosis

Question 19

Which drug interferes with the COX enzyme?

Answer 19

Aspirin

Question 20

Heparin

Answer 20

Inhibits action of thrombin, Factors X & IX

Question 21

Calcium Channel Blockers work by..

Answer 21

Reducing the force of contraction of the heart

Question 22

Captopril blocks the formation of..

Answer 22

Angiotensin 2

Question 23

Technique to diagnose a cardiac dysrhythmias..

Answer 23

ECG

Question 24

Salbutamol acts on..

Answer 24

B-receptors

Question 25

Preventers..

Answer 25

Baclomesasone
Sodium cromoglicate
Monteluskast

Question 26

Relievers..

Answer 26

Salbutamol
Salmeterol
Ipratropium
Theohyiline

Question 27

Cotransporter on the ascending limb of the loop of Henle..

Answer 27

Bumetanide

Question 28

Example of potassium sparing diuretic

Answer 28

Sprironolactone

Question 29

Diuretics

Answer 29

May cause postural hypotension

Question 30

May be used to treat acute diarrhoea

Answer 30

Opioid derivatives

Question 31

Antacids

Answer 31

Relive dyspepsia

Question 32

Can cause respiratory depression..

Answer 32

MORPHINE

Question 33

Nociceptors

Answer 33

Are sensitive to the chemical substance released by damaged cells or tissues

Question 34

What causes the symptoms of hyperthyroidism?

Answer 34

Cardiovascular system and CNS are depressed metabolism rate increases.

Question 35

What is a goitre?

Answer 35

Abnormal swelling of the thyroid gland causing a lump to form

Question 36

What causes hyperthyroidism?

Answer 36

Graves Disease,

Activation of TSH by antibodies

Question 37

Long term treatment for hyperthyroidism

Answer 37

Surgery

Radioactive Iodine

Question 38

How is Carbimazole is excreted?

Answer 38

URINE

Question 39

A drug that inhibits the synthesis of thyroxin and is the treatment for hyperthyroidism.
Converted into ACTIVE drug in the liver

Answer 39

Carbimazole

Question 40

What causes hypothyroidism

Answer 40

Not enough Iodine in diet causing insufficient T3/T4 (thyroid hormones) causing patient to need thyroxin substitute

Question 41

Severe Hypothryoidism

Answer 41

IV Triirothyronine T3