Practical 7: Exam Notes

Question 1

What five factors are examined in PT

Answer 1

1
2
5
7
10

Question 2

What factors are examined in APTT

Answer 2

1
2
5
8
9
10
11
12

Question 3

What factor is unique to PT

Answer 3

7

Question 4

What factors are found in both PT and APTT
(4)

Answer 4

1
2
5
10

Question 5

What factors are unique to APTT
(4)

Answer 5

8
9
11
12

Question 6

What factors are vitamin K affected?
Affected by warfrin

Answer 6

II

VII

IX

X (Protein C, protein S)

Question 7

What does TT measure

Answer 7

It measures the time necessary to drive the reaction of fibrinogen to fibrin in the presence of thrombin

Question 8

Which is the intrinsic and which is the extrinsic pathway of coagulation?

Answer 8

Extrinsic + common = PT

Intrinsic + common = APTT

Question 9

What would cause a prolonged TT (fibrinogen deficiency)
(6)

Answer 9

A consumptive coagulopathy

Severe liver disease

Hereditary deficiencies

Afibrinogenaemia

Dysfibrinogenaemia -> acquired (liver disease) or inherited

Inhibitors such as heparin and dabigatran

Question 10

How can you reverse the affects of anticoagulants on TT

Answer 10

Catalyse the reaction with reptilase

Unlike thrombin, reptilase is insensitive to heparin and dabigatran

Question 11

What is the equation for the Rosner Index

Answer 11

(1:1 mix clotting time result - NPP clotting time result)/ initial prolonged clotting of patient sample