PPQ Flashcards
Enrofloxacin belongs to
AMEG B
for how long should a valid veterinary prescription for antimicrobial veterinary medicinal products from the date of issue, according to the new EU regulation on verterinary medicines
5 days
gentamicin belongs to
AMEG C
how did the veterinary antimicrobial consumption change during the last 5 years in the EU
decreased
how would you describe the pharmacokinetic properties of colistin and gentamicin
adsorption of colistin and gentamicin are very slow from the GI tract
ornithobacterium rhinotracheal is frequently resistant to this antibiotic
tylosin and dirofloxacin
systemic treatment is needed in this case of otitis
suppurative otitis externa
the agent is effective against actinobacillus suis and mycoplasma hypopneumoniae in swine
enrofloxacin IM, Tulathromycin IM, and lincomycin-spectinomycin combination IM
this drug can be used for the treatment of foot rotm as it is active against anaerobic bacteria and its penetration is good
florfenicol and amoxicillin
this drug can effectively be used in cystitis in dogs if its caused by enterococci or lactamase producing e. coli
amoxicillin clavulanic acid and amoxicillin
this drug is authorised for poultry and can be effective against fowl cholera
amoxicillin
this drug is authorised in poultry and can be effective against ulcerative enteritis
phenoxymethylpenicillin
what is the route of admin for gamithromycin in swine
IM
which agent would be first line choice in chronic pharyngitis in dogs
Azithromycin
which drug belongs to the first line systemic treatments for canine pyoderma
cefalexin
which drug can be used for systemic treatment of MRSP pyoderma in dogs
rifampicin
which of the following bacteria can cause polyserositis of swine
streptococcus suis
which parameter is pharmacokinetic
Cmax
Zinc sulphate can be used topically to treat
interdigital dermatitis
‘single shot’ antiobiotics can be used against
BRDC
It is inevitable to remember the pharmacodynamic properties of certain antimicrobials to be able to reduce the spreading of resistance. Based on this knowledge macrolide antibiotics are advised to use in high dosages for short period of time
false
tulathromycin can reach effective concentration in lung and this concentration persist in lung until one week
true
Enrofloxacin is excellent in the treatment of pneumonia caused by gram negative fastidious pathogens in swine, and it is outstanding activity against Mycoplasma species.
true
Amoxicillin is authorised only for intramuscular administration in both swine and cattle.
false
As of February 2022, the prophylactic used of antimicrobials will be limited to the individual treatment of animals.
false
most common form of antiobiotics used by veterinarians is a solution and premix
true
the spread of antimicrobial resistance can be slowd down
true
From 2022, when antibiotics are added to feed, the duration of prophylactic treatment must not exceed two weeks.
false
The efficacy of oral chlortetracycline against mycoplasmas in poultry species is uncertain due to poor absorption.
false
in poultry species, tilmicosin may be most effective in treating diseases caused by spirochaete spp
false
Oral sulphonamide-trimethoprim combinations are particularly effective against mycoplasmas in poultry species.
false
The PK/PD analysis is (AUC/MIC model) helps estimate the degree of spreading antimicrobial resistance. The higher the ratio the higher the chance is for selection of mutant bacteria resistant to the given antimicrobial agent.
false
Perform a PK/PD analysis
- Cmax/MIC in case of conc dependant (MIC has to be 8-10X higher than Cmax to achieve optimum killing speed) → plasma / tissue conc have to be 10X higher than MIC for perfect efficacy
- PK analysis (liquor, lung, intestines, synovial fluid) published data -> compare drug conc at site of infection with MIC
- PD MIC determination more useful (drug resistant or susceptible but give you conc which can be compare with online data in diff tissues)
Acquired resistance to fluoroquinolone in pathogenic bacteria develops gradually and, in several stages, only after several weeks of treatment.
false
It is proven, that animal products can transfer antimicrobial resistance to people, the most important and versatile vector of it is the E. coli.
true
In case of time dependent bactericidal antibiotics their maximum concentration should be at least six times higher in the treated compartment than the MIC volume of the given antibiotic agent for the given infectious bacterium isolate.
false
Multiple causes can be present in the background of BRDS, while the treatment of which the bacterial resistance is rare. Most of the empirically suitable antibiotics can treat the disease in case of P. Multocida, M. Haemolytica and M. Boris infectious background as well.
false
In case of bovine P. Multocida respiratory disease the MIC value for ceftiofur is 0.004 mg/𝞵l. The concentration reached in the PELF, in the blood and in the pulmonary interstitial fluid is higher than the MIC value for more than 8 days. This means a correct drug choice for the treatment of the infectious disease.
true
In case of ruminant Porphyromonas levii interdigital dermatitis, although the substance can be present at the site of infection in high concentrations, using tetracycline locally is not advised due to the bacterial resistance against the substance.
false
The treatment of calf E. Coli diarrhoea depends on the severity of the animal, in case of lack of systemic symptoms the usage of antibiotic agents is not advised, fluid and electrolyte therapy are recommended.
true
For the treatment of Escherichia coli diarrhoea in weaned piglets, enrofloxacin is the best choice, taking into account pharmacokinetic, pharmacodynamic, antibiotic susceptibility and public health considerations
false
target receptor of amitraz
Octopamine rc
topically for canine pyoderma
neomycin
side effects of florphenicol
NOT KCS or anaemia- (chloramphenicol)
Which statement is true about the following sentence? Using systemic treatment is not needed in cases of intertrigo, because bacteria cannot reach deeper part of the skin in this dx
whole statement is true
general indication for AB
the product is indicated for several bacteria which are listed in the indication
NOT authorised for poultry in the EU
Chloramphenicol, gentamycin
YES: tiamulin, Tylvalosin, phenoxymethylpenicillin
Which statement is true about the following sentence? Susceptibility testing should always be performed before treating folliculitis, because bacterial susceptibility is difficult to estimate in case of deep pyodermas
whole sentence is false
this drug is very effective against fastidious bacteria and mycoplasmae as well and has excellent distribution
both of them = enrofloxacin and tulathromycin
which statement is true about foot root disease in ruminants
Interdigital dermatitis can be treated with tetracycline spray, because high, effective concentration can be reached with topical treatment at the site of infection
This drug can be used for the treatment of foot rot,as it is active against anaerobic bacteria and its penetration is good.
tulathromycin
“In PK/PD analysis for the treatment of respiratory infections,bacteria’s MIC value should be compared to the drug’s concentration in the…
all of them: blood plasma, urine, PELF= Pulmonary epithelial lining fluid
administration of colistin swine
Both of them= IM and PO= parenteral
in poultry, e.coli can cause
both of them: CRD + septicaemia also: granulomatosis + arthritis
which statement is true about BRDC
Fastidious organisms are the most frequent bacteria present. Luckily,resistance is usually low in them to most antibiotics.
single shot AB good for
None? = GI and foot infection
good for respiratory diseases
lincomycin in swine
Both PO and IM
Amox + claavulinic acid in swine
both: oral and parenterally
resistance rates are worse in this species
poultry
brachyspira hyodsentry what antibiotic can be used
tyvalosin
what is the pharmacodynamic? Cmax/MIC/both/none
Both
amoxicilin can be used against clostridia perfringens C,E. rhusiopathiae, streptocouss
all 3
antimicrobial resistance cannot be slowed down
false
mastitis good general condition, treat with intramammary infusion
true
most common form of use of medicine by vet injection
false premix + oral powder
plasmid e.coli strain in poultry
false (pigs)
as of February 2022, prophylaxis use is not allowed
false
antimicrobial in feed no longer than 2 weeks
false- 5 days for antimicrobials and 2 weeks for AB and 1 month for when not specified on the veterinary product
in ruminants fusobacterium necrophorum locally is good but systemically treatment with amoxicillin clavulanic IV
false- lincomycin, tulathromycin and fluorophenol
which drug can be found in high concentrations in macrophages
macrolides
disc diffusion method something about it cannot be used in PK/PD method
performing AB susceptibility
Bovine respiratory disease complex, M. Bovis hard to eradicate and treat, 3 drugs tulathromycin, Gamithromycin and enrofloxacin. Can be used for treatment?
true
what is florfenicol
AMEG C
what is marbofloxacin
AMEG B
colistin should be decreased by 95% in coming years
False 65%
question about metaphylaxis/prophylaxis allowed under current rules: food producing, small, allowed or not
allowed
use of fluorquinolones is prohibited in poultry
false (resistant though)
single shot of AB can be used against: GI, foot rot, both, none
NOT: GI, skin, mastitis
YES: respiratory
what drug is used in canine pyoderma: cefovecin, amoxicillin, both, none
both
gentamicin + colistin
absorption of colistin + gentamycin is very low from GI tract
AM consumption
decreased
PQ vet prescription
5 days
concentration dependent bactericidal max conc. should be 6 times higher
false
how would you determine conc in pneumonia with AB spectrum: PELF, blood plasma, urine, all 3
PELF
e. coli in calves AB susceptibility- faecal sample, severe cases blood test
true
MRSA know which systemic and which is topical
Local: mupirocin, Fusidic acid
Systemic: rifampicin, amikacin, florfenicol, chloramphenicol
tylvasin belongs to
macrolides
ceftiofur belongs to
3rd generation cephalosporin (beta-lactamase AB/ time dep bactericidal/ inhibition of cell wall synthesis)
severe mastitis
IV: flouroquinolones (marbofloxacin, enrofloxacin), tetracyclines, potentiated sulphonamides
can you use colistin in poultry
yes
how to tx a cow in drying off stage if no mastitis present
SCC is normal then give a bismuth seal (into teat canal) with combination of disenfection
should CIA drugs only be used in emergency/severe circumstances?
yes they are used as a last resort
