PPM

Question 1

What did PASE look at?

Answer 1

SND or AVB

DDDR vs VVIR

Question 2

What was the primary endpoint for PASE

Answer 2

QoL as assessed by SF36

Question 3

What was the findings of PASE?

Answer 3

Higher QoL in both groups
26% went for DDDR after PPM syndrome
28% had AF in SND+VVI compared to 19% in SND+DDD

Question 4

What did MOST look at?

Answer 4

SND

DDDR vs VVIR

Question 5

What was the primary endpoint of MOST?

Answer 5

All cause mortality or non fatal stroke

Question 6

What were the findings of MOST?

Answer 6

No difference in primary endpoint
Higher AF and HF hospitalization in VVIR
QoL higher in DDDR
PPM syndrome 20% in VVIR

Question 7

What did CTOPP look at?

Answer 7

SND or AVB

VVIR vs AAIR/DDDR

Question 8

What was the primary endpoint of CTOPP?

Answer 8

Stroke or death from cardiovascular cause

Question 9

What were the findings of CTOPP?

Answer 9

Similar rate of stroke and death
AF lower for AAIR/DDDR
HF hospitalisation and all cause mortality did not differ

Question 10

What did UKPACE look at?

Answer 10

AVB

VVIR vs DDDR

Question 11

What was the primary endpoint for UKPACE?

Answer 11

All cause mortality

Question 12

What were the findings of UKPACE?

Answer 12

No difference in mortality, AF, HF, stroke

Question 13

What did SAVEPACE look at?

Answer 13

SND

DDDR vs AAIR/DDDR

Question 14

What was the primary endpoint of SAVEPACE

Answer 14

Time to persistent AF

Question 15

What were the findings of SAVEPACE?

Answer 15

Vp 9% in AAIR/DDDR vs 99% DDDR
Less AF in AAIR/DDDR by 40%
No difference in mortality