CRT

Question 1

What did RAFT look at

Answer 1

CRTD + OPT vs ICD + OPT

Question 2

Where was inclusion criteria for RAFT?

Answer 2

II III
<30%
>120ms
Paced >200ms

Question 3

What was primary end point for RAFT

Answer 3

Death from any cause or hospitalisation for HF

Question 4

What did REVERSE look at?

Answer 4

CRT with or without ICD

Question 5

What were inclusion criteria for REVERSE?

Answer 5

Class I II
<40%
>120ms

Question 6

What was primary endpoint for REVERSE

Answer 6

HF clinical composite response (score of improved, unchanged or worsened)

Question 7

What was secondary end point for REVERSE

Answer 7

LV end systolic volume index and hospitlization for worsening HF

Question 8

What were outcomes for REVERSE?

Answer 8

CRT reduces risk of HF hospitalization and improves ventricular structure and function for Class I and II

Question 9

What did MIRACLE ICD look at?

Answer 9

CRTD vs OPT (control)

Question 10

What was the inclusion criteria for MIRACLE ICD

Answer 10

Class III IV
<35%
>130ms

Question 11

What type of trial was MIRACLE ICD?

Answer 11

Randomized, double blind, parallel controlled trial

Question 12

What was the outcome for MIRACLE ICD?

Answer 12

CRT had higher QoL and Class but no different in 6 min walk distance

Question 13

What did MIRACLE look at?

Answer 13

CRTP vs OPT (control

Question 14

What was the inclusion criteria for MIRACLE?

Answer 14

Class III IV
<35%
>130ms

Question 15

What type of trial was MIRACLE?

Answer 15

Double blind trial

Question 16

What was the primary end point for MIRACLE?

Answer 16

Class
QoL
Distance walked in 6 minutes

Question 17

What was the outcome for MIRACLE?

Answer 17

CRT had lower 40% risk of event

Question 18

What did MADIT CRT look at

Answer 18

CRTD vs ICD only

Question 19

What was inclusion criteria for MADIT CRT

Answer 19

Class I II
<30%
>130ms

Question 20

What was the primary endpoint for MADIT CRT

Answer 20

Death from any cause or non fatal HF event

Question 21

What did MADIT CRT show?

Answer 21

Reduction in HF or death in LBBB patients

Question 22

What did COMPANION look at?

Answer 22

CRTP (+/- D) + OPT vs OPT

Question 23

What was the inclusion criteria for COMPANION?

Answer 23

Class III IV
ICM or NICM
>120ms

Question 24

What was the primary endpoint for COMPANION?

Answer 24

Time to death from or hospitalisation for any cause

Question 25

What was the outcome of COMPANION

Answer 25

68% of OPT reached endpoint vs 56% of CRTP

Question 26

What did CAREHF look at

Answer 26

CRT vs CRT + OPT

Question 27

What was the inclusion criteria for CAREHF

Answer 27

Class III IV
Low EF
Wide QRS

Question 28

What was the primary endpoint of CAREHF

Answer 28

Time to death from any cause or unplanned hospitalisation for major cardiovascular event

Question 29

What was the secondary end point for CAREHF

Answer 29

Death from any cause