CRT Flashcards
What did RAFT look at
CRTD + OPT vs ICD + OPT
Where was inclusion criteria for RAFT?
II III
<30%
>120ms
Paced >200ms
What was primary end point for RAFT
Death from any cause or hospitalisation for HF
What did REVERSE look at?
CRT with or without ICD
What were inclusion criteria for REVERSE?
Class I II
<40%
>120ms
What was primary endpoint for REVERSE
HF clinical composite response (score of improved, unchanged or worsened)
What was secondary end point for REVERSE
LV end systolic volume index and hospitlization for worsening HF
What were outcomes for REVERSE?
CRT reduces risk of HF hospitalization and improves ventricular structure and function for Class I and II
What did MIRACLE ICD look at?
CRTD vs OPT (control)
What was the inclusion criteria for MIRACLE ICD
Class III IV
<35%
>130ms
What type of trial was MIRACLE ICD?
Randomized, double blind, parallel controlled trial
What was the outcome for MIRACLE ICD?
CRT had higher QoL and Class but no different in 6 min walk distance
What did MIRACLE look at?
CRTP vs OPT (control
What was the inclusion criteria for MIRACLE?
Class III IV
<35%
>130ms
What type of trial was MIRACLE?
Double blind trial
What was the primary end point for MIRACLE?
Class
QoL
Distance walked in 6 minutes
What was the outcome for MIRACLE?
CRT had lower 40% risk of event
What did MADIT CRT look at
CRTD vs ICD only
What was inclusion criteria for MADIT CRT
Class I II
<30%
>130ms
What was the primary endpoint for MADIT CRT
Death from any cause or non fatal HF event
What did MADIT CRT show?
Reduction in HF or death in LBBB patients
What did COMPANION look at?
CRTP (+/- D) + OPT vs OPT
What was the inclusion criteria for COMPANION?
Class III IV
ICM or NICM
>120ms
What was the primary endpoint for COMPANION?
Time to death from or hospitalisation for any cause
