PPI Flashcards
1
Q
CYS813 is most easily reached by PPI Y/N
A
Y
2
Q
Which CYS can only reach by less active PPI
A
CYS 822
3
Q
pls draw the structure of pyridine
A
N
4
Q
Rabeprazole depended on the CYP-mediated metabolism Y/N
A
N
5
Q
omeprazole and esomeprazole are more relied on CYP2C19 Y/N
A
Y
6
Q
why enteric coating is requried for PPI
A
prevent the protonation in the low PH environment (stomach) due to the formation of reactive intermedia (sulfenic acid)
7
Q
In addition to malabsorption, long-term use of PPI can also increase the risk of infection Y/N
A
Y
8
Q
strat w standard dose Y/N
A
Y
9
Q
how long should the inital therapy be
A
4-8 wk (re-assess)
10
Q
if inadequte control of the sx
A
try to find the cause (medication
