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Phar 3819 > IBD > Flashcards

IBD Flashcards

1
Q

MOA for methotraxate

A

inhibits dihydrofolate reductase
influecen DNA replication

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2
Q

Example of thiopurine

A

azethiopurine

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3
Q

MOA for thiopurine

A

Impair DNA repplication (purine analogue)

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4
Q

Fistula is more common in Crohn’s disease Y/N

A

Y

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5
Q

Factors contributing to crohn’s disease

A

genetic pre
environment
dysfunction of the immune response

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6
Q

Diagnosis of the Crohn’s disease

A

hx and presentation
blood test
stool test to rule out the presence of pathogens
image (ileocolonscopy / endoscopy)

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7
Q

stool calprotectin is a marker for inflammation Y/N

A

Y

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8
Q

crohn’s disease does not usually invlove ileum Y/N

A

N

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9
Q

can NSAIDs worse IBD Y/N

A

Y

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10
Q

it is not necessary to screen active infection before giving Y/N

A

N

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11
Q

5-amoinosalicylate is an-anti-inflammatory drug Y/N

A

Y

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12
Q

what is the main gold for induction therapy

A

get rid of inflammation quickly

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13
Q

induction for crohn’s disease

A

corticosteroid

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14
Q

maintenance therapy for crohn’s disease

A

methotrexate
thiopurine
biologics

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15
Q

5-aminosalicylate is a immunposuppresant Y/N

A

N

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16
Q

based on different site of inflammation UC can be divided into

A

proctitis / proctosigmoiditis / left-sided / extensive colitis / pancolitis / toxic colitis

17
Q

sx for UC

A

abdominal pain
dairrhoea (w blood and mucous)
rectal bleeding
constipation
systematic sx like fever / fatigue / weight loss / tachycardia
malnutrient
anemia

18
Q

surgeries for UC

A

toal proctocolectomy
ileoanal pouch anastomosis

19
Q

pathology of IBD

A

disturbance of the homeostasis between epithelial cells / immune cells / and gut microbes

20
Q

stool calprotectin is a essential indicator for IBD Y/N

A

Y

21
Q

stool MCS is a indicator for

A

pathogens

Phar 3819 (8 decks)

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