immunosupressant

Question 1

types of immunosupressant

Answer 1

calcineurin inhibitor
mTOR inhibitor
antimetabolite

Question 2

calcineurin inhibitor

Answer 2

ciclosporine
tacrolimus

Question 3

ciclosporin is a CYP3A4 substrate Y/N

Answer 3

Y

Question 4

same as ciclosporin, tacrolimus is also a CYP3A4 substrate Y/N

Answer 4

Y

Question 5

mTOR inhibitor

Answer 5

sirolimus
everolimus

Question 6

drug-drug interaction w ciclosporin

Answer 6

statin
diclofenac

Question 7

food-drug interaction w ciclosporin

Answer 7

food juice (grape fruit–CYP3A4 inhibitor )

Question 8

virus infection for immunocompromised patient

Answer 8

CMV
repiratory syncytial virus

Question 9

bacteria infection

Answer 9

PJP

Question 10

fingal infection and tx

Answer 10

aspergillus
tx: voriconazole

Question 11

risk factors for acute rejection

Answer 11

cold ischemia time greater than 24 hours
young recipient and old donor
presence of dornor-specific antibody
delayed onset of action
blood type mismatch
african-american ethinicity
HLA mismatch

Question 12

causes for heat transplant

Question 13

cause for kidney transplant

Answer 13

autoimmune disorder

Question 14

induction therapy is used when

Answer 14

around the time of transplant