PPH Meds

Question 1

Methergine
MOA/Dose/A/E
CIN

Answer 1

ergot alkaloid
MOA: vasoconstriction thus increases uterine contraction (and impeded uterine blood flow)
Dose: 0.20 mg IM q 2 hours up to 3 doses
A.E: n/v, HTN or hypotension
CIN: hypertension or pre-eclampsia, heart disease

Question 2

Cytotec
MOA/Dose/A/E
CIN

Answer 2

MOA: synthetic prostaglandin E1 (increased myometrial ctx)
Dose: 1000 per rectum or orally
A/E: fever, tachycardia
CIN: none

Question 3

Hemabate (methyl PGF2 alpha)
MOA/Dose/A/E
CIN

Answer 3

MOA:works on prostaglandin F receptors in uterus, causing uterine ctx
Dose: 0.25 mg IM q 15 min, up to 8 doses

A/E: N/V, flushing
CIN: presense of asthma, active cardiac/renal/hepatic disease

Question 4

Cell Saver

Answer 4

Intraoperative cell salvage (IOCS) is an autologous blood transfusion method involving collecting and processing red blood cells during a surgical procedure for reintroduction into patient’s blood circulation.10 IOCS occurs in a multi-step process involving the collection of blood from the operative field through a double-lumen suction, mixing it with an anticoagulant at the same time, washing the collected blood and filtering it through a semipermeable membrane to remove cellular debris, and then reinfusing it usually soon after initial collection.11

Question 5

Pitocin
Dose/A/E
CIN

Answer 5

30-40 units/ liter IV or 30-40 units IM
A/E: n/v, concerns for water intoxication due to ADH like effect

CIN: none