Powerpoint-Chap3 Flashcards
What happens in wound healing
angiogenesis acute inflammation fibrobast and parenchymal regeneration ECM proteins scar formation remodeling of parenchymal elements remodeling CT
What layer is critical for regeneration and restoration of tissue
the ECM
What parts of our body can completely regenerate
epidermis, GI tract, epithelium and the RBCs
does the liver truly regenerate
no, compensatory hyperplasia
what is the term resolution when talking about wound healing
complete restoration to original function
What are labile cells
continuously dividing cells from M to G1 to S to G2 to M
what are types of labile cells
epidermis, mucosal epithelium, GI epithelium and stel cells
what are stable cells
low level replication
Go to G1 to S to G2 to M
what are types of stable cells
hepatocytes, renal tubular epithelium, pancreatic acini
stem cells
what is the proliferative potential of permanent cells
almost never divide, stuck in Go
what are examples of permanent cells
CNS neurons, cardiac and skeletal myocytes
What is a totipotent stem cell
very early embryonic
what is a pluripotent stem cell
in embryo- embryonic stem cell
what is a multipotent stem cell
in fetus and adult
what is a progenitor or lineage committed stem cell
closer to final destination
what is an induced pluripotent stem cell
embed nucleus of differentiated cell into cytoplasm of oocyte
What stem cell can make the placenta and fetal membranes
the totipotent
What is transdifferentiation
non stem cell transforms into different cell type
already differentiated stem cell creates cells outside already established differentiation path
what is transduction
genes from a host cell (bacterium) are incorporated into genome of bacterial virus (bacteriophage) and then carried to another host
what are the stem cells in skel m
satellite cells
what are the stem cells of GI tract
crypt cells
what are the stem cells in liver
oval cells
what layer are the stem cells of epidermis in
the basement membrane
where are the corneal stem cells
limbus