Chapter 6 Flashcards
What type of cells are activated in a type I HS?
CD4+ TH2 responses
What are the roles of TH2 T cells
produce cytokines
IL4 and IL13 which lead to increase B cell IgE synthesis
what chemokines can cause mast cell degranulation
IL8 and adenosine
what drugs can cause mast cell degranulation
codein, morphine
what phsyical stimuli can cause mast cell degranulation
sunlight, trauma, heart/cold
What are released in the initial response of type I HS
histamine, chymase.tryptase
heparin
what are released in the delayed phase type I HS
lipid mediators LKT B4, C4, D4, E4 Porstaglandin D2 PAF TNF and IL1 IL4 for + feedback
What cells are responsible for the Ab-dep cell-mediated cytotoxicity in type II HS
NK
What are common diseases that are type II HS
Good pastures (Ab agaainst alveolar and glomerular BM)
Myasthenia Gravis
DM II
What type of HS is SLE
III IC
What type of HS is post-streptococcal glomerulonephritis
III IC
What is a disease type III HS from infectious agent
polyareteritis nodosa
what type of rxn is acute serum sickness
type III
Describe injury causes by IC deposition
activates C’
can have fibrinoid necrosis from protein accumulation
What is type IV HS
T cell mediated CD8
describe the CD4 rxn in type IV HS
DTH
TH1 with macrophages
TH17 with neutrophils
What causes CD4 switch to TH1
IL-12, then TH1 makes IFNy which increases TH1
what causes CD4 witch to TH17
IL 1,6,23 and TGFb
what is the role of IFNyin DTH
Macrophage activation increasing TNF and IL1 and IL12
what is the role of TH17 cells in DTH
recruit, activate neutrophils and monocytes
What does a granuloma look like
not around central blood vessel and lots of epithelial histiocytes
types of type IV HS
RA DM I MS Geullain Barre Crohns contact dermatitis
describe CTL component of type IV HS
granzymes and performs
CTL don’t need prior recognition of tumors or viruses
What type of HS reaction is graft rejection
type IV DTH