Potassium-sparing diuretics

Question 0

Therapeutic Effects

Answer 0

1. Diuresis (with less K+ excretion)

2. Block effects of aldosterone -> sodium / water excretion, potassium retention

Question 1

MOA

Answer 1

1. Acts on distal tubule -> block Na+ / K+ exchange & aldosterone receptors.
2. ⬆Na+ and H2O excretion while retaining K+ and H+

Question 2

Indications

Answer 2

1. HTN
2. Fluid overload / edema
3. Hyperaldosteronism

Question 3

Precautions

Answer 3

1. Impaired renal function
2. Pre-existing dehydration
3. Pre-existing electrolyte disturbances (hyperkalemia)

Question 4

Contraindications

Answer 4

1. Chronic renal failure

2. Untreated dehydration / electrolyte disturbances

Question 5

Side / adverse effects

Answer 5

1. Electrolyte disturbances = hyperkalemia

2. Weakness, dizziness

Question 6

Nursing Actions

Answer 6

Assessment: BP, I/O, BUN / Cr, K+, Mg++

Question 7

Durg example

Answer 7

Aldactone

spironolactone