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PSYC 355 > post synaptic receptors > Flashcards

post synaptic receptors Flashcards

1
Q

types of receptors

A
  1. inotropic
  2. metabotropic
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2
Q

inotropic receptors

A
  • direct channels
    l ligand gated channels
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3
Q

metabotropic receptors

A
  • G coupled receptors
  • linked to G protein
  • indirect
  • can activate enzymes
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4
Q

Structure of ACh nicotine receptor

A
  • 5 subunits
  • 2 alpha and one of each other one
  • so 2 ACh molecules must bind simultaneously
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5
Q

effect of letting sodium in

A

excitatory

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6
Q

effect of letting chlorine in

A

inhibitory

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7
Q

types of acetylcholine receptors

A
  1. nicotinic
  2. muscarinic
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8
Q

nicotinic receptors

A
  • ionotropic
  • NMJ and brain
  • nicotine is an agonist
  • curare in an antagonist
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9
Q

muscarine receptor

A
  • metabotropic
  • smooth muslce like heart and gut
  • muscarine is the agonist
  • atropine is the antagonist
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10
Q

what type of receptors are the dopamine ones

A

metabotropic

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11
Q

types of dopamine receptors

A
  1. D1
  2. D2
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12
Q

D1 receptors

A
  • activates adenyly cylcalse and increases cAMP
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13
Q

D2 receptor

A

inhibits enzyme adenylyl cyclase and decreases amount of cAMP
- blocked by antipsychotics to increase

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14
Q

GABAa receptor

A
  • inotropic
  • Inhibitory
  • takes in Cl- which causes shunt inhibition and hyperpolarization
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15
Q

benzodiazepine

A
  • enhances effect of GABAa by increasing frequency of its binding
  • valium
  • relaxes
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16
Q

barbiturates

A
  • enhances effects of GABAa by prolonging its effects
17
Q

GABAa liagnds

A
  • it has many ligands that can bind
  • the drugs themselves dont open the channels but they change the effet that GABA has when it binds at the same time
18
Q

GABAb receptors

A
  • metabotropic
  • G protein opens potassium channel and thus hyperpolarizes
  • letting k out makes it return to be more negative and thus less likely to fire
19
Q

Glutamate receptors

A
  • major excitatory because it excited and makes fire (depolarizes)
  • let in sodium
20
Q

type of glutamate receptors

A
  1. metabotropic: mGLuR
  2. inotropic: AMPA, NMDA, kainate
21
Q

AMPA

A
  • lets in sodium and potassium
  • more sodium will come in so it will depolarize and become more likely to fire
22
Q

kainate

A
  • we dont know too much about it but its similar to AMPA
23
Q

NMDA

A
  • lets sodium and calcium in only (depolarize) when enough EPSPs build up
  • voltage gated and ligand gated
  • calcium will have a host of effets and activate enzymes that will create long lasting strctural changes (like learning)

PSYC 355 (6 decks)

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