post synaptic receptors

Question 1

types of receptors

Answer 1

1. inotropic
2. metabotropic

Question 2

inotropic receptors

Answer 2

• direct channels
  l ligand gated channels

Question 3

metabotropic receptors

Answer 3

• G coupled receptors
• linked to G protein
• indirect
• can activate enzymes

Question 4

Structure of ACh nicotine receptor

Answer 4

• 5 subunits
• 2 alpha and one of each other one
• so 2 ACh molecules must bind simultaneously

Question 5

effect of letting sodium in

Answer 5

excitatory

Question 6

effect of letting chlorine in

Answer 6

inhibitory

Question 7

types of acetylcholine receptors

Answer 7

1. nicotinic
2. muscarinic

Question 8

nicotinic receptors

Answer 8

• ionotropic
• NMJ and brain
• nicotine is an agonist
• curare in an antagonist

Question 9

muscarine receptor

Answer 9

• metabotropic
• smooth muslce like heart and gut
• muscarine is the agonist
• atropine is the antagonist

Question 10

what type of receptors are the dopamine ones

Answer 10

metabotropic

Question 11

types of dopamine receptors

Answer 11

1. D1
2. D2

Question 12

D1 receptors

Answer 12

• activates adenyly cylcalse and increases cAMP

Question 13

D2 receptor

Answer 13

inhibits enzyme adenylyl cyclase and decreases amount of cAMP
- blocked by antipsychotics to increase

Question 14

GABAa receptor

Answer 14

• inotropic
• Inhibitory
• takes in Cl- which causes shunt inhibition and hyperpolarization

Question 15

benzodiazepine

Answer 15

• enhances effect of GABAa by increasing frequency of its binding
• valium
• relaxes

Question 16

barbiturates

Answer 16

• enhances effects of GABAa by prolonging its effects

Question 17

GABAa liagnds

Answer 17

• it has many ligands that can bind
• the drugs themselves dont open the channels but they change the effet that GABA has when it binds at the same time

Question 18

GABAb receptors

Answer 18

• metabotropic
• G protein opens potassium channel and thus hyperpolarizes
• letting k out makes it return to be more negative and thus less likely to fire

Question 19

Glutamate receptors

Answer 19

• major excitatory because it excited and makes fire (depolarizes)
• let in sodium

Question 20

type of glutamate receptors

Answer 20

1. metabotropic: mGLuR
2. inotropic: AMPA, NMDA, kainate

Question 21

AMPA

Answer 21

• lets in sodium and potassium
• more sodium will come in so it will depolarize and become more likely to fire

Question 22

kainate

Answer 22

• we dont know too much about it but its similar to AMPA

Question 23

NMDA

Answer 23

• lets sodium and calcium in only (depolarize) when enough EPSPs build up
• voltage gated and ligand gated
• calcium will have a host of effets and activate enzymes that will create long lasting strctural changes (like learning)