Post mid-2 Flashcards
The primary function of the chemical senses (taste and smell) is as ___ of the body. They identify things that should be consumed for survival, check if it is safe to breathe/swallow something. They have high ‘___’ rates for receptors (lots of ___), every 5-7 weeks for ___ receptors and 1-2 for ___ receptors
The primary function of the chemical senses (taste and smell) is as “gatekeepers” of the body. They identify things that should be consumed for survival, check if it is safe to breathe/swallow something. They have high ‘turnover’ rates for receptors (lots of neurogenesis), every 5-7 weeks for olfactory receptors and 1-2 for taste receptors
The 5 basic taste qualities are ..
1) Salty
2) Sour
3) Sweet
4) Bitter
5) Umami- described as meaty, brothy or savoury, associated with MSG
The taste into 5 basic qualities that can be mixed to create new combinations e.g. sweet and sour chicken is similar to …
colours that are broken down into 3 cones but can be mixed to give rise to new colours
Sweetness is associated with substances that have ___ ___ ____. Sweet compounds cause an ___ ___ response and also trigger ___ ___ responses that prepare the GI system for processing these substances.
Sweetness is associated with substances that have high nutritional value. Sweet compounds cause an automatic acceptance response and also trigger anticipatory metabolic responses that prepare the GI system for processing these substances.
Bitterness is associated with substances that are potentially ___ e.g. ___. Bitterness trigger ___ ___ responses to help the organism ___ ___ substances.
Bitterness is associated with substances that are potentially harmful e.g. toxins, poisons. Bitterness trigger automatic rejection responses to help the organism avoid harmful substances.
Salty taste indicates the presence of ___ (which are bodies need)
Salty taste indicates the presence of sodium (which are bodies need)
Though there are various examples of links between ___ ___ and a ____ ___ e.g. anticipatory metabolic responses when consuming sweet things, seeking out salty foods after being deprived/depleted, etc.
Some of these can be ___, with no perfect connections between tastes and function of substances
Though there are various examples of links between taste quality and a substance’s effect e.g. anticipatory metabolic responses when consuming sweet things, seeking out salty foods after being deprived/depleted, etc.
Some of these can be generalizations, with no perfect connections between tastes and function of substances
Our tongue contains ___ different kinds of papillae each of which contain __ __ (approx. 10,000 in total). Each __ __ consists of 50-100 __ __. The tips of these __ __ are where __ occurs (when chemicals contact their receptor sites)
Our tongue contains 4 different kinds of papillae each of which contain taste buds (approx. 10,000 in total). Each taste bud consists of 50-100 taste cells. The tips of these taste cells are where transduction occurs (when chemicals contact their receptor sites)
Tongue
the receptor sheet for taste. Contains papillae, taste buds, taste cells, receptor sites
Papillae
the structures that give the tongue is rough appearance. There are 4 kinds, each with a different shape
Taste buds
contained on the papillae, expect for the filiform papillae (Central part of tongue) which contain no taste buds- therefore must stimulate back or perimeter of tongue to result in broad range of taste sensations. There are about 10,000 taste buds.
Taste cells
cells that make up a taste bud . There are a number of cells for each bud, and the tip of each one sticks out into a taste pore. One or more nerve fibres are associated with each cells
Receptor sites
sites located on the tips of the taste cells. There are different types of sites for different chemicals. Chemicals contacting the sites cause transduction by affecting ion flow across the membrane of the taste cell
Signals from ___ __ travel along 1 of 4 nerves, which synapse with the ___ of the ___ ___ in the brain stem. They then travel to the ___, followed by areas in the __ ___ considered to be the primary receiving area for taste: ___ and ____ ___
Signals from taste cells travel along 1 of 4 nerves, which synapse with the nucleus of the solitary tract in the brain stem. They then travel to the thalamus, followed by areas in the frontal lobe considered to be the primary receiving area for taste: insula and frontal operculum
What the recordings from the chorda tympani nerve when different taste stimuli were presented to rats showed.. i.e. Erikson’s experiment
Across-fibre patterns: where there was relatively similar patterns of activation between NH4Cl and KCl (chemicals that taste similar) but different from NaCl
The results were taken as evidence for population coding. That because population coding was responsible for taste perception, taste aversion learned for KCl should generalize to NH4Cl
Evidence for specificity coding in taste
Experiment by Mueller et al. where genetic cloning was used to add PTC receptor (human bitter receptor) to see how it affected behavior.
Normal mice do not have the receptor to detect PTC, and do not avoid PTC. The mice bred with a PTC receptor avoided PTC.
Also a similar result when breeding mice that lacked the Cyx receptor (they no longer avoid Cyx, as they otherwise typically would), and no longer produced a response in nerve fibres processing signals from the tongue. Therefore, when the taste receptor for a substance is eliminated, this is reflected in both nerve firing and the animal’s behavior
Is the neural code for taste quality population coding, specificity coding or both?
Evidence exists for both specificity and population coding in taste but balance is shifting toward specificity
There are different responses to phenylthiocarbamide (___) and to 6-n-propylthiouracil (__), about ___ of people can’t perceive the taste of these compounds i.e. missing receptors to detect __/___
There are different responses to phenylthiocarbamide (PTC) and to 6-n-propylthiouracil (PROP), about 1/3 of people can’t perceive the taste of these compounds i.e. missing receptors to detect PTC/PROP
Tasters vs nontasters
- tasters have more taste buds than nontasters
- tasters also have specialized receptors for PROP/PTC that nontasters lack
Nontasters can be compared to ___ from back in the vision unit
dichromat
Supertasters
picky eaters that are more sensitive/lower threshold to bitter substances than tasters. This may be evolutionary advantageous
Many animals are macrosmatic meaning they..
have a keen sense of smell necessary for survival e.g. dogs
Humans are microsmatic meaning …
we have a less keen sense of smell that is not crucial to survival
Macrosmatic animals communicate through phermones which are …
molecules emitted by members of a species that results in a specific reaction in, or communication with, another individual of the same species
Anosmia
loss of smell
Why is it that rats are 8-50x and dogs are 300-10,000x more sensitive to odours than humans?
Even though the individual receptors of all these animals are equally sensitive the difference lies in the NUMBER of receptors they each have. With humans have 10 million and dogs have 1 billion olfactory receptors
Humans can ___ more than 1 trillion different odours (compared to several million colours, half a million tones) but find it difficult to __ odours, only successful about half of the time
Humans can discriminate more than 1 trillion different odours (compared to several million colours, half a million tones) but find it difficult to identify odours, only successful about half of the time
Some molecules that have similar structures smell ___, and some that have different structures smell __
Some molecules that have similar structures smell different, and some that have different structures smell the same
Olfactory mucosa is located above the __ ___ (below the __ __)
Olfactory mucosa is located above the nasal cavity (below the olfactory bulb)
Reasons for why odours are difficult to identify is ..
that there are no big brain regions for smell (and taste) like vision or hearing, this may make identification less accurate as evolutionary we rely more on vision
Maybe because of an inability to retrieve the odours name from our memory
Odourants are carried via an airstream entering the nose and come into contact with the ___ ___ ___ (ORN) embedded in this mucosa, which contain ___ ___ sensitive to a narrow range of odourants (‘___’) e.g. similar to tastebuds
Each ORN consists of ___ type of receptor.
Estimates for humans range from having about ___-___ types of these receptors
Odourants are carried via an airstream entering the nose and come into contact with the olfactory receptor neurons (ORN) embedded in this mucosa, which contain individual receptors sensitive to a narrow range of odourants (‘tuned’) e.g. similar to tastebuds
Each ORN consists of just one type of receptor.
Estimates for humans range from having about 350-400 types of these receptors
Chemical senses involve 3 components
taste, olfaction, flavor (combination of taste and olfaction)
Why neurogenesis (renewal of receptors )happens
because the receptors that serve taste and smell are constantly exposed not only to the chemicals they are designed to sense but also to harmful materials such as bacteria and dirt
Taste accomplishes its gatekeeper function by the connection between ___ ___ and a ___ ____
Taste accomplishes its gatekeeper function by the connection between taste quality and a substance’s effect
Population coding vs specificity coding
specificity coding: quality is signalled by the activity in individual neurons that are tuned to respond to specific qualities
population coding: quality is signalled by the pattern of activity distributed across many neurons
People who can taste PTC are ___, and those who cannot are called ___
People who can taste PTC are tasters, and those who cannot are called non tasters
Detection threshold for odours
lowest concentration at which an odorant can be detected
One method for measuring detection threshold is forced-choice method in which participants..
with blocks of two trials - one trial contains a weak odorant and the other, no odorant. The participant’s task is to indicate which trial has a stronger smell
odor object
source of an odour e.g. coffee, bacon, rose etc.
Perceptual organization role in odour
There may be hundreds of molecules from different odour objects e.g. coffee, orange juice, bacon that are mixed in the air but the person just perceives “coffee”, “orange juice” and “bacon”. Perceiving these few odour objects from hundreds of intermixed molecules
How odour objects are perceived
(a) odorant molecules enter the nose
(b) flow over the olfactory mucosa, which contains 350 different types of olfactory receptor neurons (ORNs)
(c) stimulation of receptors in the ORNs
(d) activates the ORNs
(e) signals from the ORNs are then sent to glomeruli in the olfactory bulb and then
(f) to higher cortical areas
Parallel and difference between visual pigments and olfactory receptors
Parallel:
- both sensitive to a specific range of stimuli- each type of visual pigment is sensitive to band of wavelengths in a particular region of the visible spectrum and each type of olfactory receptor is sensitive to a narrow range of odourants
- just as a particular rod or cone receptor contains only 1 type of visual pigment, a particular olfactory receptor neuron (ORN) contains only 1 type of olfactory receptor
Difference:
- while there are only 4 different types of visual pigments (1 rod pigment and 3 cone pigments), there are about 400 different types of olfactory receptors, each sensitive to a particular group of odourants
___ corpuscles (___) are primarily responsible for sensing vibration
Pacinian corpuscles (RA2) are primarily responsible for sensing vibration
Corpuscle
(a minute body or cell in an organism) structure surrounding Pacinian receptors is responsible for the selective response to vibration
The corpuscle only transmits __ ___ (like vibration) to the actual receptor, not ___ __
The corpuscle only transmits repeated pressure (like vibration) to the actual receptor, not continuous pressure
The corpuscle can be likened to an ___ in form, consisting of a series of layers with ___ between each layer
The corpuscle can be likened to an onion in form, consisting of a series of layers with fluid between each layer
Surface texture
refers to the physical surface created by peaks and valleys on a given material
Visual inspection often leads to inaccurate perception of ___, in part due to variation in what ___ is visible when __ is inconsistent
Visual inspection often leads to inaccurate perception of texture, in part due to variation in what texture is visible when illumination is inconsistent
Katz proposed that perception of texture depends on 2 cues which are..
spatial cues, temporal cues (more accurate when using both)
Spatial cues are determined by…
the size, shape, and distribution of surface elements
e.g. large bumps or grooves that may be visible, which can be felt simply by pressing one’s skin against the material (but can also be felt when moving one’s skin across the material- aggregation of all timepoints)
Temporal cues are determined by …
the rate of vibration as skin is moved across finely textured surfaces
e.g. finer textures, like sandpaper, which in fact require movement across the skin (not passive like spatial cues) to be accurately perceived
Historically, much of the work directed at understanding perception of texture has focused on ___ cues
Historically, much of the work directed at understanding perception of texture has focused on spatial cues
Hollins and Reisner: two different fine textures were perceived as identical when _____, yet could be distinguished when participants ____
Hollins and Reisner: two different fine textures were perceived as identical when passively touched, yet could be distinguished when participants moved their hand across them
There is higher degree of accuracy and specificity when you use spatial/temporal cues
temporal
Hollins et al. adapted participants’ skin in 1 of 2 conditions:
1. 10-Hz (10 vibrations/second) stimulus for 6 minutes to adapt to the ___ corpuscle (because these receptors respond best to low frequencies)
- 250-Hz stimulus for 6 minutes to adapt the ___ corpuscle (because these receptors respond best to high frequencies)
Participants asked to repeatedly discriminate amongst 2 fine surface textures - e.g. one fine vs one very fine (therefore chance performance =50%)
Adaptation to the ___-Hz stimulus (only) affected the perception of fine textures
Implicates the role of ___ cues, mediated by the ___ corpuscle receptor, in sensing fine texture
Hollins et al. adapted participants’ skin in 1 of 2 conditions:
1. 10-Hz (10 vibrations/second) stimulus for 6 minutes to adapt to the meissner corpuscle (because these receptors respond best to low frequencies)- Meissner corpuscle disabled
- 250-Hz stimulus for 6 minutes to adapt the Pacinian corpuscle (because these receptors respond best to high frequencies)- Pacinian corpuscle disabled
Participants asked to repeatedly discriminate amongst 2 fine surface textures - e.g. one fine vs one very fine (therefore chance performance =50%)
Adaptation to the 250-Hz stimulus (only) affected the perception of fine textures
Implicates the role of temporal cues, mediated by the Pacinian corpuscle receptor, in sensing fine texture
Active touch refers to
tactical perception that involves controlled movement, usually with hands and fingers - temporal cues
Passive touch refers to
directly applying something to the skin, without any movement e.g. as when testing two-point thresholds)- spatial cues
___ perception relies on active touch to explore 3-D objects and can be thought of as engaging (at least) 3 distinct systems, which entails a great deal of complex coordination for the perceptual system:
1) ___ system
2) ___ system
3) ___ system
Haptic perception relies on active touch to explore 3-D objects and can be thought of as engaging (at least) 3 distinct systems, which entails a great deal of complex coordination for the perceptual system:
1) Sensory system
2) Motor system
3) Cognitive system- memory, schemas, previous experiences
Psychophysical research shows that people can identify many objects using ___ perception in 1-2 seconds
Psychophysical research shows that people can identify many objects using haptic perception in 1-2 seconds
Lederman and Klatzky have shown people use 4 primary exploratory procedures to identify objects: __ __, ___ __, __, __ . They typically rely on 1 or 2 of these to make judgements about a particular property e.g. to judge texture vs to judge exact shape
Lederman and Klatzky have shown people use 4 primary exploratory procedures to identify objects: lateral motion, contour following, pressure, enclosure . They typically rely on 1 or 2 of these to make judgements about a particular property e.g. to judge texture vs to judge exact shape
Neurons in the ventral posterior nucleus (functions in touch) have ___-___ ___ __ (like in the LGN)
Neurons in the ventral posterior nucleus have centre-surround receptive fields (like in the LGN)
Some somatosensory neurons respond maximally (are ‘tuned’) to particular ___ and/or __ of ___
Some somatosensory neurons respond maximally (are ‘tuned’) to particular orientations and/or direction of movement
Some neurons in the monkey somatosensory cortex also respond best to particular kinds of ___ __
Some neurons in the monkey somatosensory cortex also respond best to particular kinds of hand grips
___ can also modulate the response of neurons in S1 and S2 (neurons in the somatosensory that are sensitive to touch)
Attention can also modulate the response of neurons in S1 and S2 (neurons in the somatosensory that are sensitive to touch)
Hsiao, O’Shaughnessy & Johnson: Raised letters e.g. Braille run across monkey hands in 1 of 2 conditions, either requiring attention on the tactic sensation or some other unrelated visual stimuli
Much more robust firing of neurons in S1 and S2 in the ____ condition
Hsiao, O’Shaughnessy & Johnson: Raised letters e.g. Braille run across monkey hands in 1 of 2 conditions, either requiring attention on the tactic sensation or some other unrelated visual stimuli
Much more robust firing of neurons in S1 and S2 in the tactile-attention condition- because distracted from tactile sensation by the visual stimuli so neurons did not fire as strongly
Keysers et al. showed that S2 neurons respond to ____, but not ____
Similar results when watching someone else use ___ touch to explore objects
Keysers et al. showed that S2 neurons respond to seeing someone else be touched, or seeing an object being touched, but not a control film with similar visual properties –> mirror neurons
Similar results when watching someone else use active touch to explore objects
Pain
a multimodal phenomenon (e.g. visual information like a scary needle or auditory like a loud sound) containing a sensory component and an affective or emotional component e.g. stressed before going to dentist can make pain feel worse
Inflammatory pain
caused by damage to tissues and joints or by tumour cells
Neuropathic pain
caused by damage to the CNS
Nociceptive pain
caused by activation of nociceptors in the skin, which signal impending damage. Respond to heat, chemicals, severe pressure and cold
Threshold of eliciting nociceptor response requires ___: need to warn the system of damage without being oversensitive i.e. not be triggered by ‘normal’ everyday activities
Threshold of eliciting nociceptor response requires balance: need to warn the system of damage without being oversensitive i.e. not be triggered by ‘normal’ everyday activities
The direct pathway model of pain …
was an early theory that assumed pain is simply the result of nociceptors being stimulated and sending signals to the brain
A problem with the direct pathway model of pain was that there was a lot of evidence for many kinds of exceptions like…
- pain can be affected by a person’s mental state
- pain can occur when there is no stimulation of the skin i.e. placebo
- pain can be affected by a person’s attention
- phantom limbs- limbs hurt where there is none
Like the direct pathway model, ___ ___ model still assumes that pain signals enter the spinal cord from the body and are transmitted to brain
However, in addition…
Like the direct pathway model, gate control model still assumes that pain signals enter the spinal cord from the body and are transmitted to brain
However, in addition…
It says that various kinds of additional pathways exist that influence the transmission of these signals to the brain, effectively opening or closing a ‘gate’ that these signals flow through
The various kinds of additional pathways that the gate control model mentions, involves __ types of signals processed in the __ __ of the spinal cord, whose integrated output is sent to what are referred to as ___ __ (whose activity is directly related to our perception of pain)
The various kinds of additional pathways that the gate control model mentions, includes involves 3 types of signals processed in the dorsal horn of the spinal cord, whose integrated output is sent to what are referred to as transmission cells (whose activity is directly related to our perception of pain)
The 3 different signals in the gate control model of pain
signals from mechanoreceptors (not considered painful stimuli), signals from nociceptors (painful stimuli), signals from the central control (top-down mediating effects e.g. distraction)
Mechanoreceptors
receptors carrying information about non-painful tactile-based stimuli
They send inhibitory signals (-) to transmission cells, closing the gate
Nociceptors
receptors carrying information about painful tactile-based stimuli
They send excitatory signals (+) to transmission cells, opening the gate
Central control
receive signals related to cognitive function e.g. attention, expectations, distractions etc.
They also send inhibitory signals (-) to transmission cells, closing the gate
__ __ __ has been used to keep patients’ attention on other stimuli than the pain-inducing stimulation
Virtual reality technology has been used to keep patients’ attention on other stimuli than the pain-inducing stimulation