Population genetics/ Counseling

Question 1

• Population genetics definition?
• Equation?
• Assumptions? (5)
• Ethical issue Du Jour?

Answer 1

• Study of allele frequencies and change in allele frequencies
• p (common allele) +q (rare allele) =1
  p^2 + 2pq +q^2 = 1
• large pop with random mating, allele freq. remains constant, no rate of mutation, all genotypes are equally fit, no immigration with different freuqncies
• MD’s influence allele frequency

Question 2

• Goals of counseling? (4)
• Basic tenets? (3)
• Ethical issues? (4)

Answer 2

• Comprehend facts, understand hereditary, understand recurrent risk and options, adjust to condition
• educate, non directive, unconditional, supportive
• patient autonomy, benefeficience, non malefeance, justice