Population Genetics

Question 1

Among 4.5 million births in one population during a period of 40 years, 41 children diagnosed with the autosomal dominant condition aniridia were born to normal parents. Assuming that these cases were due to new mutations, what is the estimated mutation rate at the aniridia locus?

Answer 1

41/(4.5million x 2)

Then divide by 2 generations (20 yrs/gen)