Population Genetics Flashcards
Mendelian population
Group of interbreeding, sexually reproducing individuals with a common set of genes
The gene pool is characterized by
Genotypic frequencies, allelic frequencies
Genotypic frequency
Proportion of a particular genotype
Frequency of an allele=
f(A)= (2(AA)+(Aa))/2N
Allelic frequency
Copies at allele/copies of all alleles at locus
Frequency with more than 2 alleles
A1= (2(A1A1)+1(A1A2)+(A1A3))/2N
Frequency of sex linked alleles
Allele 1
Female- 2*X1X1+X1X2
Male-X1Y
(WHEN ADDING FOR WHOLE POPULATION, ADD MALES AND FEMALES!)
Hardy Weinberg equilibrium assumptions
No natural selection
No mutation
No migration
Large population
Random mating
What does the hardy weinberg equilibrium predict?
Allelic frequency won’t change
Genotypic frequency stabilizes after one generation in proportions
Hardy weinberg equation
p^2+2pq+q^2
Positicve assortive mating
Like individuals mate
Negative assortive mating
Non like individuals mate
Inbreeding
Related individuals mate preferentially
Inbreeding depression
Reduced fitness due to increase in recessive traits
How do mutations create new alleles?
Making new proteins