polymorphism

Question 1

first phase once a drug has been taken

Answer 1

distribution phase

Question 2

how to estimate the volume distribution

Answer 2

backstrapolate

Question 3

interdose fluctuation

Answer 3

to reduce this we can give the same total dose in a day but more frequent

example: if the dose is 5000 once day we can break it into two 250 doses

Question 4

vitamin/ supplements can interfere with what?

Answer 4

vitamin interferes with absorption

Example: think about grapefruit and its interaction with cardiovascular medication

Question 5

aminoglycoside:

absorption

Answer 5

not absorbed orally

Question 6

aminoglycoside:

distribution:

Answer 6

• low lipid solubility
• little protein binding
• volume distribution is small

Question 7

aminoglycoside

metabolism

Answer 7

none

Question 8

aminoglycoside

excretion

Answer 8

primarily renal

Question 9

gentamicin, tobramycin, amikacin

Answer 9

aminoglycoside

Question 10

aminoglycoside:

half life

Answer 10

upper limit of kidney function

2-4hr

Question 11

BCHE deficiency and prolonged neruomuscular blockade

Answer 11

succinylcholine

Question 12

acetylation status and neurotoxicity

Answer 12

isoniazid

Question 13

G6PD deficiency and hemolytic anemia

Answer 13

animalarials

Question 14

Genetic polymorphims [2]

Answer 14

1. SNPs

2. Indels–> insertions and deletions

Question 15

pro-drug anti-platelet drug

Answer 15

clopidrigel (plavix)