Drug response Flashcards
exam 1
1
Q
EC50 is > or < than Kd
A
EC50 < kd; we don’t have to occupy all the receptors to get a response
2
Q
drug that is the most potent
A
has the highest affinity
3
Q
Emax
A
efficacy
4
Q
Ec50 (concentration) or ED50 (Dose)
A
affinity and potency
5
Q
competitive inhibitor
A
shift to the right
6
Q
noncompetitive antagonist or partial agonist
A
Max. efficacy not reached
7
Q
LD50
A
lethal dose
8
Q
drugs that pass most readily through cell membranes
A
non-ionized
9
Q
for weak acids, the protonated form is _______
A
non-ionized
10
Q
for weak bases, the protonated form is ______
A
ionized
11
Q
what determines the amount of ionization of a drug?
A
pH
12
Q
Blood pH
A
7.4
13
Q
ionized at low pH
A
base
14
Q
ionized at high pH
A
acid
15
Q
is it good at binding a receptor?
A
affinity
