Polycystic kidney disease Flashcards
1
Q
Define
A
Autosomal dominant disease where cysts replace kidney tissue
2
Q
Aetiology?
A
Genetic= PKD1 on Chr 16, PKD2» mutations that can be passed on to offspring
3
Q
Pathophysiology?
A
Proliferation of tubular epithelium of kidneys
The cysts form, are attached to tubules and then they detach when greater than 2mm in diameter
The cysts damage adjacent nephrons when they get big enough
4
Q
Presenting symptoms?
A
Hamaturia
Berry aneurysms (maybe SAH)
Flank pain
Palpable kidneys» LUQ
5
Q
Signs?
A
Palpable kidneys on LUQ
6
Q
Ix (4)
A
US
CTKUB
Genetic testing
MRI» check for SAH
7
Q
Main complication from PCKD?
A
Berry aneurysms leading to SAH
