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Genetics of cell growth and division > polarised secretion > Flashcards

polarised secretion Flashcards

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Biology 101 flashcards
1
Q

what is the secretory pathway essential for?

A

growth of PM, deposition of cell wall and membrane proteins, secretion of molecules to the outside, post translational modifications

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2
Q

what happens when you have mutations in secretory pathway?

A

cell division stops but lipid syntheisis continues

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3
Q

what were ts sec mutants secretion blocked?

A

secretion of invertase and acid phosphatase

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4
Q

phenotype of sec 20 and 23 mutants?

A

large ER

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5
Q

phenotype of sec7 mutants

A

berkeley bodies- enlarged golgi

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6
Q

phentoype of sec1 mutants

A

large secretory vesicles

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7
Q

what is the epistatic order if events?

A

sec20-sec7-sec1. ER- golgi- vesicles

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8
Q

what are the 2 classes of early mutants

A

class1- vesicles to golgi. class 2- ER to golgi

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9
Q

what is the glycosylation of mutants blocked in ER exit?

A

only have core glycosylation so are smaller

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10
Q

what are the 5 classes of secretion mutants?

A

A- accumulation incytosol. no transport into ER. B- accumulation in rough ER. class C-accumulation in vesciles. D- accumulation in golgi. E-proteins accumulate in secretory vesciles

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11
Q

sec4 is synthetically lethal with what other proteins?

A

late secretory group proteins

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12
Q

what is sec4s GEF?

A

sec2

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13
Q

what else in sec4 dependent upon?

A

myo2 and actin

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14
Q

what protein is required for actin stability?

A

tropomyosin

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15
Q

when 1 genes for tropomyosin knocked out and other made ts, what happens at restrictive temp?

A

actin cables dissapear and sec4 not polarised

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16
Q

what are formins required for?

A

actin cable assembly at bud tip and neck

17
Q

2 redundant formins in yeast

A

Bnr1 and Bni1

18
Q

what proteins are in the exocyst?

A

sec15,3,5,6,8,10 and Exo70

19
Q

what protein does sec4 physically associate with?

A

sec15

20
Q

what is sec3 loclaisation dependent upon?

A

cdc42,cdc28 and rho1. not dependent upon actin cables

21
Q

what does ypt31 recruit?

A

sec2 and 4. and activiated. also activates sec15. sec4 also recruits myo2

22
Q

what does cdc42 recruit?

A

polarisome and actin cables are formed from this

23
Q

what does the exocyst associate with?

A

sec4

24
Q

what proteins does the exocyst bind on PM?

A

sec3 and exo70

Genetics of cell growth and division (9 decks)

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