Polar groups and hydrogen bonds

Question 1

What types of non-covalent bonds drive drug-target interactions (5)

Answer 1

1. Van der Waals interactions
2. Dipole bonds
3. Chelation and complexation
4. Ionic Bonds
5. Can be cleaved in physiological conditions - reversible

Question 2

What types of covalent bonds drive drug-target interactions (3)

Answer 2

1. Alkylation reactions
2. Acylation reactions
3. Too strong to be cleaved in physiological conditions - irreversible

Question 3

What are non-covalent bonds in drug-binding mechanisms (3)

Answer 3

1. The most common binding mechanism for drugs
2. weaker than covalent bonds
3. However, non-covalent bonds can undergo multiple interactions, resulting in globally stronger bonds than one covalent bond.

Question 4

What are dipole interactions in drug-binding mechanisms (2)

Answer 4

1. Occurs when the electronegativity is between 0.5 and 1.6
2. Occurs between permanent dipoles or ions and dipoles

Question 5

What are hydrogen bonds in drug-binding mechanisms? (2)

Answer 5

1. Occurs when a hydrogen can bridge between two electronegative atoms
2. one forming a covalent bond and the other a non-covalent bond

Question 6

What chelation and complexation in drug-binding mechanisms

Answer 6

Occurs when one or more electron-rich atom(s) bind to a metal