Points from end of week 1 test

Question 1

What cell or structure is responsible for Vit D metabolism ?

Answer 1

Keratinocytes

Question 2

What is the function of collagen (found in the dermis)?

Answer 2

Provide tensile strength

Question 3

What cells carry out epidermal proliferation ?

Answer 3

Basal cells

Question 4

How long does it take cells to migrate from the basal layer to the keratin layer ?

Answer 4

28 days

Question 5

Where do cells in the skin start to loose their nuclei (become enucleated)?

Answer 5

Nuclei loss starts in the granular layer and is complete in the keratin layer.

Question 6

What enzyme is deficient in erythropoietic protoporhyria ?

Answer 6

Ferrochelatase

Question 7

What are nails made up off ?

Answer 7

Made up of hard densely packed keratin (therefore more closely related to hair rather than bone)

Question 8

Match the following layers with the associated cells/structures:

• Basal layer
• Prickle layer
• Granular layer
• Keratin layer

Highly metabolically active small cuboidal cells, Odland bodies, Corneocytes, Polyhedral cells with lots of desmosomes

Answer 8

• Highly metabolically active small cuboidal cells – Basal layer
• Odland bodies – Granular layer
• Corneocytes – Keratin layer
• Polyhedral cells with lots of desmosomes – Prickle cell layer

Question 9

What is the enzyme which is deficient in acute intermittent porphyria ?

Answer 9

Porphobilinogen deaminase (PBG deaminase)

Question 10

What percentage of GP consultations are skin problem related ?

Answer 10

Around 19%

Question 11

Match each of the pictures to the correct descriptive feature of skin disease:

Crust, Fissure, Erosion, Maceration, Ulcer, Linchenification, Scale, Atrophy

Answer 11

1. Crust
2. Fissure
3. Erosion
4. Maceration
5. Ulcer
6. Linchenification
7. Scale
8. Atrophy

Question 12

What cells protect DNA from UV radiation ?

Answer 12

Melanocytes by making melanin

Question 13

Match the following skin gland with the appropriate function below:

• Apocrine
• Eccrine
• Sebaceous

Skin Lubrication, Moisten plams/soles for grip, Scent glands

Answer 13

• Apocrine - scent glands
• Eccrine - Moisten palms/soles for grip
• Sebaceous - Skin lubrication

Question 14

What cells produce collagen ?

Answer 14

Fibroblasts

Question 15

Panton valentine leukocidin is a cytotoxin associated with highly virulent strains of _________ causing necrolytic skin infections

Answer 15

Staph. aureus (e.g. MRSA)

Question 16

What feature allows topical steroids to passively diffuse across the plasma membrane ?

Answer 16

They are lipophilic

Question 17

What is some of the effects of topical steroids ?

Answer 17

They are anti-proliferative, anti-inflammatory and vasoconstrictive

Question 18

Match the picture to the appropriate description of the skin lesion:

Plaque, Wheal, Vesicle, Bulla, Pustule, Macule, Nodule, Papule

Answer 18

1 – Bulla, 2 – Papule, 3 – Plaque, 4 – Pustule, 5 – Nodule, 6 – Wheal, 7 – Vesicle, 8 – Macule

Question 19

Do the end of week 1 test

Answer 19

Do it - https://delta.dundee.ac.uk/mod/quiz/view.php?id=982