Pneumonia and TB Flashcards
What is pneumonia?
- Acute infection of lung parenchyma.
- Associated with significant morbidity and mortality rates.
- Pneumonia and influenza are eighth leading cause of death in the United States.
What is the etiology of pneumonia?
Normal defense mechanisms:
Air filtration, epiglottis closure over trachea, cough reflex, mucociliary escalator, and reflex bronchoconstriction; IgA, IgG, alveolar macrophages
Defense mechanisms become incompetent or overwhelmed
Aspiration, tracheal intubation, air pollution, smoking, viral URI, aging, chronic diseases
Table 27-1
What are the different classifications of pneumonia?
- May be classified according to causative organism, characteristics of disease, or radiographic appearance.
- Most effective classification:
Community-acquired pneumonia (CAP)
Hospital-acquired pneumonia (HAP) - Helps identify most likely organism and antimicrobial therapy.
Table 27-2
What is community-acquired pneumonia (CAP)?
- Acute infection in patients not hospitalized or residing in a long-term care facility within 14 days of the onset of symptoms.
- Can be treated at home or hospital depending on age, VS, mental status, comorbidities, and condition.
What is hospital-acquired pneumonoa?
- Occurs 48 hours or longer after hospitalization and not present at time of admission.
- Ventilator-associated pneumonia occurs more than 48 hours after endotracheal intubation.
What is empiric antibiotic therapy?
- Starting treatment before definitive diagnosis based on: Risk factors Early versus late onset Presentation Underlying medical conditions Hemodynamic stability Most likely causative organism
What are the types of pneumonia?
- Viral - most common, and may be mild or life-threatening.
- Bacterial - may require hospitalization
- Mycoplasma- atypical
- Aspiration
- Necrotizing
- Opportunistic
What is the pathophysiology of pneumonia?
- Inflammatory response
Attraction of neutrophils
Release of inflammatory mediators
Accumulation of fibrinous exudates, rbc’s and bacteria. - Alveoli fill with fluid and debris (Consolidation)
- Increased production of mucous (Airway obstruction)
- Decreased gas exchange
- Resolution of infection
Macrophages in alveoli ingest and remove debris.
Normal lung tissue restored.
Gas exchange returns to normal.
What are the most common clinical manifestations of pneumonia?
- Most common Cough: productive or nonproductive Green, yellow, or rust-colored sputum Fever, chills Dyspnea, tachypnea Pleuritic chest pain. - Older or debilitated pt: confusion, stupor, or hypothermia.
What can we find in a physical examination for pneumonia?
- Fine or coarse crackles.
- With consolidation
Bronchial breath sounds
Egophony
Increased fremitus - With pleural effusion
Dullness to percussion
What is MDR?
Multidrug-resistant pathogens - major problem in treatment
What are risk factors for pneumonia?
- Advanced age
- Immunosuppression
- History of antibiotic use
- Prolonged mechanical ventilation
- Atelectasis
- Pleurisy
- Pleural effusion
- Bacteremia
- Pneumothorax
- Acute respiratory failure
- Sepsis/septic shock
- Lung abscess
- Empyema
How can we diagnose pneumonia?
- History and physical examination
- Chest x-ray (Fig. 27-3)
- Thoracentesis and/or bronchoscopy
- Pulse oximetry
- Arterial blood gases (ABGs)
- Sputum gram stain, culture & sensitivity
- Ideally before antibiotics started
- Blood cultures
- ## CBC with differential
What are pneumococcal vaccines?
- Prevent Streptococcus pneumoniae
- Examples: Prevnar 13 and Pneumovax 23
Table 27-5
How do we treat pneumonia?
- Prompt antibiotics
- Response generally occurs within 48-72 hours
- Decreased temp
- Improved breathing
- Decreased chest discomfort