Pneumonia Flashcards
Pneumonia
inflammation of the alveoli, distal airways,
interstitium
Inflammation due to infection is called pneumonia (T/F?)
True
Non- infective pneumonia types and location
seen in interstitium
o Idiopathic interstitial pneumonitis
(idiopathic pulmonary fibrosis)
o Connective tissue disorders
How does organisms get into the airways in pneumonia
- Inhalation
- Aspiration
- Haematogenous spread
- Direct spread form mediastinum
MC way of MOs entry in pneumonia
Inhalation
Why does organisms enter in pnenumonia
- Defect in host defences
o Specific
o Non specific – Systemic (old age,
alcoholism, immunosuppression,
institutionalization), local (smoking,
COPD) - Virulent organism
- Large infective dose
Main types of classification of pneumonia
- Community acquired pneumonia
o Typical lobar pneumonia
o Atypical - Hospital acquired pneumonia
o Early
o Late
o Ventilator-associated pneumonia - Aspiration pneumonia
- Pneumonia in immunocompromised host
MO associated with ventilator- associated
Acenatobacter
Who are at higher risk of getting aspiration pneumonia
Unconscious patients
alcoholics
swallowing disorders
Typical MOs causing pneumonia
o Streptococcus pneumoniae
o Haemophilus influenzae
o Staphylococcus aureus
o Klebsiella pneumoniae
o Pseudomonas aeruginosa
Atypical MOs causing pneumonia
o Mycoplasma pneumoniae
o Legionella species
o Respiratory viruses (influenza)
o Chlamydia pneumoniae
CAP typical lobar pneumonia MOs
o Streptococcus pneumonia
o Haemophilus influenza
CAP atypical pneumonia MOs
o Mycoplasma pneumonia
o Legionella species
o Respiratory viruses
Streptococcus pneumonias aka
Pneumococcus
Clinical features of pneumonia
- Vary from mild to severe
- Fever with chills & rigors
- Cough
- Dyspnoea
- Pleuritic pain
- Systemic symptoms
o Myalgia, headache
o Confusion - Febrile, tachycardic, tachypnoeic
Signs of typical pneumococcal pneumonia
signs of lobar consolidation
Signs of Pneumonia due to atypical organisms
more systemic Sx
Signs are not localized
Difference between typical and atypical
TYPICAL
Onset- sudden
Fever- High
Chills, rigors - Usual
Sputum - Mucopurulent
Hemoptysis - Common
Lung signs - consolidation
Effusion- common
CXR - Alveolar
Response to Rx- Yes
ATYPICAL
Onset- Gradual
Fever- not High
Chills, rigors - unusual
Sputum - not prominent
Hemoptysis - uncommon
Lung signs - few
Effusion- uncommon
CXR - interstitial
Response to Rx- No
Mendelson Syndrome
Chemical pneumonitis due to aspiration.
Eg- Emergency C- section
Fever w chills and rigors DDs
Pyelonephritis
Cholangitis
Abscess
Malaria
why is aspiration causing pneumonia in the apical or posterior segment of the Right lower lobe segment
Right bronchi is wider, shorter and more in-line with the trachea
Dx tests done for pneumonia
CXR
Microbiology - Gram stain, Sputum cullture, ABST, blood culture, urinary antigens
Supportive tests done for pneumonia
FBC
ESR
CRP
BUN
SpO2, ABG
ECG
findings of pneumonia
CXR- air bronchogram
Air bronchogram
can see airways inside the consolidated area
supportive tests findings of Pneumonia
FBC- high neutrophils
High ESR, CRP
blood cultures will be positive only in
severe cases of pneumonia
Rx of pneumonia depends on
Home vs hospital
General ward vs ICU
Home Rx for pneumonia is considered in
patients who are at a state of taking and complying with pills
Hospital based treatment for pneumonia is considered in
- Vital signs
o PR>120 bpm
o RR>30/min
o Temp >400C - Radiograph
o Multi lobar involvement
o Complications (abscess, effusion) - Co-morbities (diabetes, heart failure,
COPD, malignancies, renal failure) - Systemic complications (hypotension,
confusion, oliguria) - Advanced age
- Unable to take oral drugs
- Poor family/social support
ICU care for pneumonia is considered in
- Hypoxameia (PaO2<60 mmHg)
- Hypercarbic (PaCO2> 50 mmHg)
- Acidotic
- Hypotensive (DBP <60, SBP < 90)
- Oliguric (UOP < 30)
- Uraemic
- Confused
CURB 65
Pneumonia is severe if 2 or more of the
following are present
* Confusion
* Blood urea > 7 mmol/L
* Respiratory rate > 30/min
* Diastolic blood pressure < 60 mmHg
* Age > 65
* Multi lobar
* PaO2 < 8kPa (60 mmHg)
* Blood culture is positive
ABx therapy is based on
- Suspected organism
- Patient & underlying conditions
- Availability
- Cost
ABx therapy for ambulatory patients with typical lobar consolidation previously well young adult
o Amoxicillin (pneumococcal)
o Macrolide (drug resistant SP)
Interstitial shadowing with systemic
feature (atypical pneumonia) ABx
Macrolide (clarithromycin)
Co-morbidities present ABx therapy for ambulatory patients with pneumonia
o Respiratory
fluroquinolones
(levofloxacin)
o Amoxicillin / clavulanate PLUS
macrolide
ABx therapy for hospitalized patients
- Respiratory fluroquinolone (moxifloxacin,
levofloxacin oral or i.v.) - Beta lactam (cefotaxime, ceftriaxone) i.v.
PLUS macrolide (clarithromycin