Pneumocystis Flashcards
Who is the at risk population for pneumocystis?
PCP only affects the immunocompromised
What is unique about the fungus PCP in terms of cell membrane molecules?
PCP does NOT have ergosterol in its cell membrane.
Can pneumocystis be grown in vitro?
NO
Describe the reproduction of pneumocystis
It as asexual and sexual reproduction. A cyst form and a trophozoite form.
Describe the habitat of pneumocystis
Data suggests that >80% of people are infected by 4 years of age but these infections are asymptomatic!
How is pneumocystis transmitted?
the airborne route, person to person.
When is pneumocystis disease initially observed in immunocompromised pts?
When the CD4 count drops <200.
How does PCP present? Acute, subacute, chronic?
Subacute, evolves over 1-2 weeks.
Initial symptoms of PCP
fever, non-productive cough, shortness of breath, weight loss and night sweats.
What is the pathogenesis of PCP?
It primarily attacks the interstitial fibrous tissue of the lungs causing marked thickening of the alveolar septa and alveoli.
What is the complication/primary cause of death in PCP?
Respiratory Failure–> Death
Is it common to have extra pulmonary infection with PCP?
No, it is only in severe disease and it has a high mortality.
diagnosis of PCP?
- Imaging studies
- Appropriate samples from lung or disseminated sites
- Direct microscopic examination to observe for trophozoites and cyst formation
- Molecular detection tests: most sensitive and specific.
Treatment of PCP
DIFFERENT THAN OTHER FUNGAL INFECTIONS
How long is treatment duration for PCP?
21 days
