PN Flashcards

1
Q

Indications for PN

A

diffuse peritonitis, obstruction (unable to bypass), intractable N/V, inadeq intestinal absorption, GI ischemia, ileus, unable to place TF, nutrient req more than able to be met via GI tract

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2
Q

Duration of PN

A

over 7 days

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3
Q

CHO Source: Glycerin ? cals/gram

A

4.3= sugar alcohol

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4
Q

PRO Source: Renal uses

A

Essential AA, dillute

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5
Q

Hepatic AA

A

Branched chain AA with dec AAA

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6
Q

Stress AA

A

Branch chain AA with normal AAA

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7
Q

FAT Source: If egg allergy

A

test dose 1cc/min x 30 mins

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8
Q

FAT component in US

A

soybean

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9
Q

How much Vit C in standard MVI for PN

A

200 mg

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10
Q

How much thiamin/folic acid in standard MVI

A

6 mg/600 mcg

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11
Q

Extra zinc (4-30 mg/d) for what reasons?

A

diarrhea, ulcer, wounds, aid GI Fx, drugs Ampho B, cisplatin, diuretics

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12
Q

Iron Dextrose in what kind PN

A

2:1 only

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13
Q

Sodium Ferric gluconate

A

not compatible

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14
Q

Iron Sucrose

A

neonatal AA 2:1

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15
Q

Dec L-carnitine in what GI d/o

A

fat malabsorption

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16
Q

2:1 PN uses what filter

A

.2 micron (better)

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17
Q

3:1 PN uses what filter

A

1.2 micron (larger particles get thru)

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18
Q

PPN Facts

A

3-7 days, good veins (PIVs), osmolarity 600-900, phlebitis risk, large total volume, not good with renal failure, CHF

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19
Q

High osmolarity components

A

AA 10 mosm/gram, Dextrose 5 mosm/gram, Ca Gluc 1.4/meq, K/Na 2/meq

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20
Q

Dextrose rule

A

3-5g/kg/min or 7g/kg/day Safe Practice Guidelines

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21
Q

Fat rule

A

2.5g/kg/day (adult)

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22
Q

Cath occlusion-thrombic

A

instill anti-thrombotic agent, drug/lipid precipitation

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23
Q

Cath occlusion- non-thrombic

A

drug related (identify drug), HCl-Acid or Na Bicarb-base

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24
Q

Inc LFTs r/t PN Tx

A

transaminases (Inc LFTs)-suspect PN if occur after PN 2 weeks, normalizes with d/c PN

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25
Inc Alk Phos
seen with bone disease
26
Inc Bilirubin
GB sludge/stones, seen often in peds with jaundice
27
Hepatobiliary Complications caused by what
Multifactorial, disease, excess Gluc, 24hr infusion, lack of enteral stimulation, bacterial overgrowth in sm bowel, infection/sepsis, sterols in IV fat (toxicity)
28
What level of Inc TG in PN Tx do you adjust therapy
Max 400, dec IVFE 400-500, hold IVFE over 500-immunosuppresants, poor glucose control
29
Essential Fatty Acid Deficiency s/s
Fat free 2-4 weeks, altered PLT, hair loss, poor wound, dry scalp/skin.
30
Supplement Ess FAcid Def
2-4% total kcals as IVFE, 1-2% linoleic acid
31
Metabolic Bone disease from CPN
CPN over 1 year, 40-100% CPN pts with malabsorption, chr liver, immobile, steroids, loop diuretics, heparin
32
Metabolic Bone Dz- what labs show this
inc Ca/PO4, urine net loss Ca/Mg, Vit D (def/toxicity)
33
Conditions that increase urine Ca+ excretion
High PRO (2g/kg/d), High Na, chr metab acidosis, excess fluid, Hyperglycemia, Alum contaminates, steroids, loop diuretics, cyclic PN infusion
34
Safe Aluminum amounts in LT PN pts
5mcg/kg/d, AA replaced with crystalline from protein hydolysates
35
Low Ca associated with low
Magnesium
36
Bone disease reported in infants with what lacking from PN formulation
Copper
37
Example Stability in PN
Maillard reaction (browning), Photodegradation by light (B vits), hydrolysis (Vit C)
38
Incompatiibility in PN
physically alters end product
39
Ca/Phos stability
pH < 5.3 or > 10 of AA, use Ca Gluconate or Ca, gluceptate, lack mixing, storage conditions, add Phos than other additives before Ca
40
L-cysteine in peds PN AA to lower pH
unfavorable for IVFE
41
Aluminum
store in plastic, excretes kidney but binds to transferrin, not more 25,mcg/L, toxicity with renal dz, Fe def, high intake in PN, AA,Ca, Phos have affinity for bind with aluminum
42
Aggregation (flocculation)
fat particles aggregate to form larger droplets but redisperse with agitation.
43
Creaming
Large fat droplets rise to surface= cream layer but REVERSE with agitation.
44
Coalescence
fat droplets aggregate into larger but irreversible, can't use PN
45
Oiling out
total separation oil/water phases- unusable PN
46
2004 Safe Practice Guidelines for Ordering PN: Mandatory
clarity of form, ingred listed same order as bag label, avoid decimals/percents, all components amt/day, contact # for provider, location of CL, ht/wt/dosing wt, dz, PN indication, hangtime guidelines, infusion rate
47
PN label: Mandatory
amt daily or kg/day (peds), dose wt, route admin, admin date/time, exp date, overfill is stated, PO4 in mmol and mEq salts, rate cc/hr or cycle, who prepared and reviewed sol'n, additives for pt to add in HCPN
48
Who developed PN/when
late 1960s Dudrick
49
3:1 sol'n when developed
1980
50
PPN Facts
5-10% Dext, 3% AA, high total volume, mild-mod malnourished, short duration up to 2 weeks
51
Indications for PPN
good PIVs, tolerate volume, @ least 5 days, no more than 2 weeks, NOT SEVERLY Malnourished
52
Contraindications PPN
Severely Malnourished, sever metabolic stress, lg nutrient/lytes needs, fluid restriction, over 2 weeks, renal/liver compormise
53
Pre-op PN
In mod/severe malnutrition pts
54
PN beneficial for
crohns flare, GI fistulae, extrese SBS, critical care pts NPO for long time, nectrotizing pancreatitis, failed EN, pulm aspiration
55
Severe Malnutrition Defined as
over 10% involuntary wt loss x 2-3 months, lower 75% DBW/UBW, prealb less 10, transferrin less 100, inadequate po greater than 7 days
56
Contraindicated PN
well nourised pt, inadequate EN, less 7 dyas, DNR
57
GI indications for PN
Crohns flare with fistula
58
PN not beneficial in GI
bowel rest not needed for crohns, mild, acute, chronic or relapsing pancreatitis less 7 days, could harm mild pancreatitis, EN favored for severe acute pancreatitis
59
PN in Periop Malnutrition
Malnutr inc OR complications, benefit fro mod malnourished for OR or upper GI Cancers. Benefit for severely malnourished. Less than 7 days=inapp.
60
PN in critical illness
EN is #1
61
PN in Cancer
PN with chemo/rad increases infections, unclear with BMT, associated with net harm
62
Comorbidity that influences pt's response to therapy/outcome
Malnutrition
63
Decrease phlebitis in PN
K less 60meq/L, heparin, piggyback IVFE, osmolarity less/equal 900 mosm/L
64
Essential Fatty acid deficiency test
High oleic/palmitoleic acids & Low linoleic/arachidonic acids, Mead acid is present (by product of oleic)
65
Increases circulating plasma TG
10% IVFat (contains inc concentrations of phospholipids)
66
FAT Daily
1g fat/kg/day
67
Prevent EFAD
2-4% t. cals
68
Correct EFAD
8-10% t cals
69
Fibrin Sleeve
inability to aspirate blood
70
Vessel thrombosis
resistance to infusion/aspiration- may have neck distension, edema, tinglin or pain over ipsilateral arm/neck, tight feeling in throat--may result permanent vascular obstruction