Pmoc Synthetic Drugs

Question 1

No piperazine quinolones

Answer 1

Nalidxic acid
Cinoxacin
Oxalimic acid

Question 2

2nd class
Has piperazine
7th positin

Answer 2

Norfloxacin
Enoxacin
Ciprofloxacin
Ofloxacin
Lomefloxacin
Sparfloxacin

Question 3

MOA of quinolones

Answer 3

Inhibition of DNA gyrase
Highly polar quinolones enter porins to cell
Ineffective to anaerobic gram-negative an

Antagonize gaba receptors
Unable to penetrate BBB

Question 4

Interfere with DNA gyrase/ inhibit dna synth during bacteroa replication
Active against gram negative bacteria
Not effective to pseudomonas
7-hydroxymethyl metabolite is active
Tx UTI

Answer 4

Nalidixic acid

Question 5

Action of First generation quinolone

Answer 5

Moderate gram-negative and minimal systemic distribution

Question 6

Example of first gen quinolone

Answer 6

Cinoxacin nalidixic acid oxolinic acid

Question 7

Action of second gen quinolones

Answer 7

Expanded gram negative and atypical pathogen coverage but limited gram-positive act

Question 8

Example of second generation quinolones

Answer 8

Class I- lomefloxacin,norfloxacin and enoxacin
Class II- ofloxacin, ciprofloxacin