PLN Flashcards
Albumin has an overall _____ charge
Negative
AGTII, Thromboxane, and ET-1 are all _______ substances
Vasoconstrictive
4 key features of nephrotic syndrome:
Hypoproteinemia (decreased TP)
Proteinuria
Hypercholesterolemia
Ascites
PLN should be on your radar if proteinuria has been present for how long?
At least 2 weeks
If UPC is >2, patient likely has:
Glomerular disease
If UPC is <2, patient might have:
Glomerular or tubular disease
UPC >0.5 with an inactive sediment is characteristic of:
Glomerular disease
Normal UPC in a dog is ______
< 0.5
Normal UPC in cats is:
< 0.4
(Ideally, less than 0.2)
4 differentials for hypoalbuminemia?
PLN
PLE
Liver failure
Blood loss
Defining feature of PLN on a chem profile is ______
Hypercholesterolemia
5 differentials for Hypercholesterolemia?
PLN
Recent meal
Lipid disorder
Cushing’s
Hypothyroidism
Contraindications for renal biopsy?
Severe, chronic azotemia
Moderate- severe Hypertension
Severe uremia
Severe chronic azotemia is a contraindication for renal biopsy for 2 key reasons:
Chronic, Severe azotemia = you’re likely just going to find irreversible fibrosis
Azotemia causes platelet dysfunction; patient is at increased risk of bleeding!!
What is severe uremia a contraindication for renal biopsy?
Risk of bleeding!
Uremia causes platelet dysfunction, patient can’t clot as well!