Platelets Flashcards

1
Q

RR for platelet count

A

150,000-400,000/mm³

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2
Q

what does the platelets help initiate

A

the coagulation cascade

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3
Q

<50,000 or >1 million are the clinical values for what count?

A

platelets count

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4
Q

platelets are integral to

A

hemostasis

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5
Q

high platelets levels

A

can be associated with increase clotting risk

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6
Q

what type of platelet count in needed to maintain vascular integrity

A

5 to 10 thousand

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7
Q

30-50k platelet count

A

moderately increased risk of bleeding

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8
Q

10-30k platelet count

A

severely increased risk of bleeding (don’t transfuse plt unless bleeding-but not common)

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9
Q

less than 10k platelet count you should _____ because the bleeding risk is _______

A

transfuse, severely increased risk

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10
Q

what is considered an increased platelet level

A
greater than 400,000 
suggest
 malignancy 
Polycythemia vera
Postsplenectomy syndrome
Drugs
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11
Q

if a patient shows signs of
Polycythemia vera
Postsplenectomy syndrome what would you consider?

A

an increased platelet level

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12
Q

what drugs can cause an increased platelet level

A

testosterone
estrogen
oral contraceptives

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13
Q

conditions associated with Thrombocytopenia

A

Leukemia
Cirrhosis
DIC (disseminated intravascular coagulation)
Anemia

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14
Q

which types of anemia are associated with Thrombocytopenia

A

Hemolytic

Pernicious

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15
Q

Thrombocytopenia types, which is more rare

A

ITP (Idiopathic Thrombocytopenic Purpura)
TTP (Thrombotic Thrombocytopenic Purpura

TTP is rare

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16
Q

what platelet count is associated with Thrombocytopenia

A

a decreased level <100,000/mm3

17
Q

ITP is more common

A

children and AIDS patients

the prognosis is better in children

18
Q

ITP etiology

A

Autoimmune

Patient develops antibodies against their own platelets

19
Q

where does massive phagocytosis of platelet-antibody immune complexes occur in ITP

A

the spleen

20
Q

ITP presentation history

A

Pt usually asymptomatic EXCEPT for mucosal & skin bleeding due to decreased platelets
Pt may have had antecedent viral infection

21
Q

a patient presents with petechiae, purpura, epistaxis, menorrhagia what would you consider for a diagnosis?

A

ITP

22
Q

a patients labs come back with Platelet count markedly low, usu. < 10,000 (10)
but other blood counts & peripheral smear normal, what would you consider for a diagnosis?

A

ITP

23
Q

treatment and prognosis for. ITP

A

Usu. self-limited in children

In adults prescribe corticosteroids

If unresponsive to medical therapy, possible splenectomy

50-60% will develop chronic ITP