Platelets

Question 1

Where do platelets come from

Answer 1

Megakaryoctyes

• DNA duplicated but cell not split
• pieces (no nucleus) shed off and last 10 days in blood

Question 2

Platelet Summary

Answer 2

Structure
1. Membrane
phospholipids (coagulation process to form fibrin clot)
2. Granules (assist aggregation, adhesion, coagulant activity of platelets)

Function:
form platelet plug
provide phospohlipid surface for coagulation cascade (fibrin clot formation)

Testing:
Platelet count, mean platelet volumue
Bleeding time
Platelet Function Assay
- epi long - drug effect on platelet clotting
- both long - platelet dysfunction
platelet glycoprotein receptors
Bone Marrow
Platelet antibody testing

Question 3

What are qualitative platelet disorders

Answer 3

Congenital/Inherited
-Bernard
-Glanzmanns
-Gray platelet syndrome
-May Heglin anomaly
Aquired
-Drugs
-Uremia
-Myeloproliferative disorders

Txt:
supportive care
platelet transfusions

Question 4

What will hemostatic disorders or connective tissue disorders be construed as

Answer 4

Child abuse

Question 5

Txt for Menorrhagia

Answer 5

Birth control pills
Lysteda
Mirena