Hematopoietic Cell Transplantation Flashcards
1
Q
Hematopoietic stem cell
A
cell that can renew itself and differentiate into a variety of cells
- harvested from bone marrow
- peripheral blood
- umbilical cord blood
2
Q
Hematopoietic cell transplant
A
series of procedures:
- treated with chemo/radiation
- Myeloablative (destroy all)
- nonmyeloablative (destroy some)
- infusion of hematopoietic progenitor stem cells
Indications for: AML ALL CLL CML MM lymphomas Sickle cell aplastic anemia B-thalassemia
3
Q
Types of HCT donors
A
autologous - self syngeneic - identical twin - low GVHD risk allogenic - someone other than person with disorder - high GVHD risk and infection risk
4
Q
HCT recovery phase
A
hospital 2-6 weeks
abx/antifungal/antivirals prophylaxis
5
Q
Prengraftment (day 0 - 30) infections
A
Neutropenic fever - pneumonia, lower GI infection, C diff Mucositis - painful diarrhea Pneumonia Vascular catheter-assoc cellulitis Blood stream infections Hepatitis
6
Q
Early Postengraftment (Day 30 - 100) infections
A
GVHD residual mucositis neutropenias Pneumonia (aspergillus) diarrhea Hepatitis Hemorrhagic cystitis Encephalitis
7
Q
Late Postengraftment (day > 100) infections
A
GVHD encapsulated bugs pneumonias (COP) hepatitis hemorrhagic cystitis varicella skin lesions encephalitis diarrhea
8
Q
Medical problems post HCT
A
CV dx Pulm dx Liver dx (iron overload) Renal dysfunction Endocrine dysfunction dermatologic issues oral health ocular issues have to redo vaccines secondary malignancy
9
Q
Monitoring post HCT
A
CBC w/ diff LFT ferritin UA Bun/Cr TSH vit D 1 yr - eye exam ekg, echo cancer center survivorship program
