Platelet Disorders Flashcards
Factor 11 deficiency
Post op bleeding
vW disease
Most common, not always symptomatic
Mucocutaneous bleeding (can cause Fe deficiency w/ reactive thrombocytosis)
Check vWF activity, antigen and factor 8 activity
Lupus anticoagulant presence
Prolonged pTT
No history of bleeding or brusiability
Hemophilia A
Prolonged PTT
Intramuscular bleeding, joint bleeding
X-linked
Factor 12 deficiency
Elevated PTT but asymptomatic
Vitamin K deficiency
Poor nutrition, elevated PT
Consumptive coagulopathy
Hemangioma
Thrombocytopenia
Elevated PT
Idiopathic/immune thrombocytopenia purpura
Immune disorder - antibodies or disregulated immune system
Platelets attacked and removed by macrophages
Treated with steroids and IgG
Inherited thrombocytopenia condition
Family history
Mucocutaneous bleeding, heavy menses
Factor 8 deficiecny
Antibodies against Ab, more serious bleeding
DIC
Increased D-dimer, PT & PTT
Schistocytes
Decreased fibrinogen
TTP
Normal fibrinogen, normal PT/PTT, hemolysis, schistocytes
Defect in ADAMTS13, can’t cleave vWF multiyear
HELLP
Lower extremity edema, right upper quadrant pain, petechiae, thrombocytopenia
Elevated liver enzymes
Schistocytes
Deliver baby
Bernard Soulier syndrome
Deficiency in GP1b
Enlarged granulated platelets
Heavy menses, mucocutaneous bleeding, easy bruising
Glanzmann thrombasthenia
Deficiency in 2b/3aT
Thrombotic microangiopathy
Microthrombi, platelets consumed, RBC destroyed (MAHA) - forming schistocytes
TTP, hemolytic uremic syndrome, complement mediated TMA, drug induced TMA
Drug induced TMA
MAHA, decreased platelet, decreased ADAMST13
Treat with plasma exchange to remove
Drug induced thrombocytopenia
Can be caused by immune mechanism, BM suppression, drugs like quinine or penicillin
HIT
Induced by heparin
Activation of platelets cause thrombosis, thromboctyopenia
