Plasma Cell Disorders

Question 1

Plasma cell disorders

Answer 1

Secrete monoclonal Ig

Question 2

MGUS

Answer 2

Asymptomatic, premalginant plasma cells

Less than 3 monoclonal protein and less than 10% plasma cells

No CRAB

Question 3

Smoldering myeloma

Answer 3

Can progress to active myeloma but no CRAB

M protein greater than 3, plasma cells between 10-60%

Question 4

Active myeloma

Answer 4

Malignant, increased plasma cells

M protein greater than 3 OR plasma cells greater than 10% WITH ONE CRAB

CD38, 138

Question 5

Solitary plasmacytoma

Answer 5

Plasma cell mass in bone or extra medullary

Clonal, no M protein in serum, no SLIM CRAB

Question 6

Waldenstroms macroglobulinemia

Answer 6

Increased B lymphocytes, IgM - hypervicous blood

Greater than 10 percent lymphoplasmacytic cells in BM

MYD88 mutation

Question 7

Amyloidosis

Answer 7

Protein folding disorder

CONGO RED staining, identify clone

Question 8

POEMS syndrome

Answer 8

Polyneuropathy, organomegaly, endocrinopathy, skin changes, monoclonal plasma cells