plasticity + functional recovery of brain after trauma Flashcards
plasticty
-shaped or molded easily
-in brain: its braisn ability to adapt as a rresult of experince or learning
-can adapt functionally or physically
infancy
-kids learn fast
-rapid growth in synaptic transmissions
-reach around 15,000 connectiosn between ages 2-3yrs nearly 2x as many as human brain
-we dont keep all connections
synaptic pronning
-as we age:
1) rarely used connections r deleted
2) frequently used ones are strengthened
-allows r brain to have life long plasticity, where new neural connections r formed in response to new demands on the brain
gray matter
-contains neuronal cell bodies
-found in outer cortex of brain
white matter
-primarily consists of myelinated axons
-found closer to the center of the brain
ao3
Draganski et al (2006)
-scanned the brains of medical students three months before and just after final exams
-Changes were found in the hippocampus and parietal cortex
ao3
Negative plasticity
The brain’s adaptation to prolonged drugs use leads to poorer cognitive functioning in later life (Medina et al, 2007)
ao3
Age and plasticity
-40 hours of golf training produced changes in neural representations of movement in participants aged 40-60
-The researchers used fMRI and observed increased motor cortex activity in the novice golfers compared to a control group
functional recovery
-example of plasticity
-brains ability to redistribute or transfers functions usually formed by a damage area to another undamaged area
-
spontaneous recovery
-FR can happen quickly after trauma
-this process can slow down after several weeks/months
-plasticty slows w age
- after this, redistribution therpay can be used to help indivual w/ their recovery (neurorehabilitation)
what happens during functional recovery?
-brain rewire+ reoraganise istelf by forming new synaptic connections close to area of damage
-neural pathways that arent normally used to carry out specific function will activate
-neural regnation + neural reorganisation can occur thru diff egs of structural change
ao3 support
schneider et al (2014)
-more time ppl w/traumatic brain injury had spent in education, greater chances of disaability free recovery
-40% those w/disability free recovery had 16yrs +education, 10% who had 12 yrs
-had to score 0 to be disability free
-collects quantitive data
-0 doesnt exclude possibility of subtle functional challenges
-retested after yr of injury
CP: FR should work for all this shows it doesnt. quantitive=not open pic
ao3 support
Baneriee et al (2014)
-Treated people with a total anterior circulation stroke (TACS)
- treated w stem cells (cells that can specialise into any cell) in a medical trial
-The recovery rate for this trial was 4% higher than the typical recovery rate
-Only 5 participants were used
-The treatment was intrusive (they had to put the stem cells into the participants)
-No control group was used
ao3 strength
neurohabilitation
-sucess of it=strength of fr
-the industry of axanol growth has been able to contribute to how well therapy works
-understanding of fr allows medical pros to know when to intervene
structural chnages fr
Axonal sprouting
The growth of new nerve endings which connect with other, undamaged nerve cells to form new neural pathways