Plasmodium, Babesia, Leishmania, Trypanosomes Flashcards

1
Q
A

Plasmodium falciprum schizont

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2
Q
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Plasmodium falciprum early troph

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3
Q
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Plasmodium vivax early trophozoite

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4
Q
A

Plasmodium malariae early troph

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5
Q

Leishmania tropica

A

infection route: phlebotomus (sand fly), multiplies in human macrophages

geography: urbal middle east

Lab test: skin scrapings, H+E stain, find amastigotes

pathology: Oriental sore, tropical sore, or Old World Cutaneous Leishmaniasis

skin ulcerations - self healing

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6
Q

Leishmania braziliensis

A

Life cycle: same as L. mexicana (Lytzomyia mosquito)

Geography: South america

Lab Diagnosis: nose cartilage biopsy

Pathology: Espundia (mucocutaneous nose disfiguration)

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7
Q
A

Plasmodium vivax developing troph

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8
Q

Leishmania major

A

vector - Phlebotomus sand fly

human host - multiplication in macrophages

geography: rural middle east, afghanistan, africa

Lab test: skin scrapings, H+E stains, find amastigotes

pathology: self healing sore

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9
Q

Trypanosoma brucei

A

Life cycle: vector teste fly, trypomastigotes in blood, lymph, CSF

Geography: West Africa (chronic) , East Africa (actue)

Lab Diagnosis: thick/thin smears, w/ tryapnosomes

Pathology: African Sleeping Sickness. Winterbottoms sign, fever, headache, coma

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10
Q

Plasmodium vivax

A

Life cycle: anopheles, blood transfusion, congenital geography: tropics, subtropics, temperate climates Lab tests: thick/thin blood smears, molecular method, serology Pathology: Benign tertian ( 48 hr), quartan ( 72 hr), benign tertian, 24 hr May present first with headache, photophobia, muscle aches, anorexia, nausea, sometimes vomiting Paroxysms - chills, shivering - fever, sweats merozoites released and produce the fever

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11
Q
A

Plasmodium falciprum troph

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12
Q
A

Plasmodium ovale gametocyte

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13
Q

Plasmodium ovale

A

life cycle: anopheles, blood transfusion, congenital geography: west africa, south pacific lab tests: thick/thin blood smear, molecular, serology Pathology: same as P malariae, and P vivax

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14
Q
A

Plasmodium ovale troph

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15
Q
A

Plasmodium malariae troph

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16
Q

Leishmania donovanii

A

Life cycle: Phlebotomus, transfusions, sexual contact, inefected macrohages throughout body

Geography: India, Middle East, Brazil

Lab diagnosis: bone marrow biopsy, liver biopsy, 3N culture media, PCR, rk39 antigen test

Pathology:

  • fever, chills, headache, weakness, progressive anemia, anorexia
  • Kala azar – black fever, in light colored people grayish discoloration of skin and having a fever
  • Co-infection with HIV seen in France, Spain, Italy*(mnemonic: FSI)
17
Q

Babesia spp.

A

Route of infection

Vector for B. microti: Ixodes scapularis blood transfusions, congenital

Geography – WW, where there are Black-legged ticks/(deer ticks – old name); East coast to Minnesota, Texas, Babesia organisms: WA1-Washington State, CA1-Calif, MO 1- Missouri; Babesia divergens- like- Washington state

Lab Diagnosis

Thick and thin blood films; serologic/immunologic studies; indirect fluorescent-antibody test; PCR tests

CAN BEE SEEN OUTSIDE RBC’s (Maltese cross)

Pathology - paroxysms – fever, chills, headache, muscle ache

18
Q
A

Plasmodium vivax gametocyte

19
Q
A

Plasmodium ovale schizont

20
Q
A

Plasmodium falciprum gametocyte

21
Q

Plasmodium falciprum

A

life cycle: Anopheles mosquito, blood transfusions, congenital Geography: tropics Lab tests: thick/thin prep, molecular methods, serology Pathology: Malignant tertian - paroxysms Cerebral malaria - coma, death; anemia Black water fever - hemolysis ( RBC’s lysing) seen in urine

22
Q

Leishmania mexicana

A

Life cycle: same as L. tropica, and L. major LUTZOMYIA mosquito

Geography: southern texas to south america

lab test: tissue biopsy (cutaneous)

Pathology: new world cutaneous Leishmaniasis

23
Q
A

Plasmodium ovale early troph

24
Q

Trypanosoma cruzi

A

Life cycle: reduvid bug — humans (trypomastigotes in blood)

route of infection: fecal route, blood transfusions

Geography: central and south america

Lab diagnosis: thick smear (Giemsa stain), thin smear( Wright-Giesma stain) C-shape, immunassay tested in donated blood

Pathology: Chaga’s disease, cardiomyopathy, megacolon, megaesophagus, (CHE) Ramona’s sign (eyelid swollen)

25
Q
A

Plasmodium malariae schizont

26
Q

Plasmodium malariae

A

Life cycle: anopheles, blood transfusion, congenital geography: ww Labs: thick/thin blood smear, molecular, serology pathology: Benign tertian ( 48 hr), quartan ( 72 hr), benign tertian, 24 hr May present first with headache, photophobia, muscle aches, anorexia, nausea, sometimes vomiting Paroxysms - chills, shivering - fever, sweats merozoites released and produce the fever

27
Q
A

Plasmodium malariae gametocyte

28
Q
A

plasmodium vivax schizont