Plasma Regulatory proteins for complement

Question 1

Dissociates C1r and C1s from C1q

A. C1 inhibitor (C1NH)
B. MCP (CD46)
C. Factor I
D. C4 Binding Protein
E.S-Protein Vitronectin
F-DAF (CD55)
G. MIRL (CD 35)
H. C4 binding Protein

Answer 1

A. C1 inhibitor (C1NH)

Question 2

cleaves C3b and C46

A. C1 inhibitor (C1NH)
B. MCP (CD46)
C. Factor I
D. C4 Binding Protein
E.S-Protein Vitronectin
F-DAF (CD55)
G. MIRL (CD 35)
H. C4 binding Protein
I. Factor H

Answer 2

Factor I

Question 3

Acts as a cofactor with I to inactivate C4b

A. C1 inhibitor (C1NH)
B. MCP (CD46)
C. Factor I
D. C4 Binding Protein
E.S-Protein Vitronectin
F-DAF (CD55)
G. MIRL (CD 35)
H. C4 binding Protein
I. Factor H

Answer 3

D. C4 Binding Protein

Question 4

-Found on virtually all epithelial and endothelial cells except erythrocytes.

is the most efficient cofactor for Factor I-mediated cleavage of C3b.

It also helps to control the alternative pathway because binding of Factor B to C3b is inhibited

A. C1 inhibitor (C1NH)
B. MCP (CD46)
C. Factor I

Answer 4

B. MCP (CD46)

Question 5

Acts as a cofactor with I to inactivate C4b
A. C1 inhibitor (C1NH)
B. MCP (CD46)
C. Factor I
D. C4 Binding Protein
E.S-Protein Vitronectin
F-DAF (CD55)
G. MIRL (CD 35)
H. C4 binding Protein
I. Factor H

Answer 5

H. C4 binding Protein

Question 6

Prevents attachment of the C5B67 complex to cell membrane

A. C1 inhibitor (C1NH)
B. MCP (CD46)
C. Factor I
D. C4 Binding Protein
E.S-Protein Vitronectin
F-DAF (CD55)
G. MIRL (CD 35)
H. C4 binding Protein
I. Factor H

Answer 6

E.S-Protein Vitronectin

Question 7

Dissociates C2b or Bb from binding sites, thus preventing formation of C3 convertase

C. Factor I
D. F DAF (CD55)

Answer 7

F-DAF (CD55)

Question 8

Prevents insertion of C9 into cell membrane

E.S-Protein Vitronectin
F-DAF (CD55)
G. MIRL (CD 35)
H. C4 binding Protein
I. Factor H

Answer 8

G. MIRL (CD 35)

Question 9

Cofactor with I; mediates transport of immune complexes It is found mainly on peripheral blood cells

G. MIRL (CD 35)
H. C4 binding Protein
I. CR1 (CD35)

Answer 9

I. CR1 (CD35)

Question 10

It binds C3b and C4b but has the greatest affinity for C3b.

H. C4 binding Protein
I. CR1 (CD35)

Answer 10

I. CR1 (CD35)

Question 11

Once bound to CR1, both C4b and C3b can then be degraded by Factor I.

G. MIRL (CD 35)
H. C4 binding Protein
I. CR1 (CD35)

Answer 11

I. CR1 (CD35)