Plasma Cell Disorders

Question 1

What is a Chronic Lymphoproliferative Disorder?

Answer 1

Clonal, malignant proliferation of B and T lymphocytes

Question 2

What is a type of leukemia that mainly affects men over 50 and is a clonal proliferation of B lymphocytes?

Answer 2

Chronic Lymphocytic Leukemia
Most common chronic leukemia
Smudge cells

Question 3

What is characteristic of Chronic Lymphocytic Leukemia and how do we diagnose it?

Answer 3

Hairy mononuclear cells
Stained with Tartrate Resistant Acid Phosphatase (TRAP)

Question 4

What are the symptoms of Sezary syndrome?

Answer 4

Mycosis Fungoides
Thick, scaly, red, itchy areas
May be mistaken for monocytes

Question 5

The presence of Reed-Sternberg cells or “owl’s eye” describes which disease state?

Answer 5

Hodgkin’s Lymphoma

Question 6

Where do plasma cells evolve from?

Answer 6

B lymphocyte

Question 7

What is caused by an overproduction of cells?

Answer 7

Multiple Myeloma

Question 8

Which disorder do we find increased ESR and Bence Jones protein in urine?

Answer 8

Multiple Myeloma

Question 9

When do we find increased IgM causing interference, overproduction of IgM, and Cryoglobulins that lead to Raynaud’s Phenomenon?

Answer 9

Waldenstrom’s Macroglobulinemia