plasma

Question 1

how many coagulation factors are contained in 1 mL of plasma (assumed)

Answer 1

1 IU
- dosage of plasma determined by body weight

Question 2

describe cryoprecipitate
- indication
- use
- contents

Answer 2

• hypofibrinogenemia, factor 8 deficiency
• for fibrinogen replacement
• fibrinogen, vWF, F8, 5 and 13

Question 3

fibrinogen mg contents in cryoprecipitate

Answer 3

150 mg per bag
- patients should have 100 mg/dL fibrinogen in 30 dL plasma

Question 4

how is cryoprecipitate prepared

Answer 4

prepared for transfusion by thawing
- pool expires 4 hrs
- single expires 6 hrs

Question 5

describe the difference between FFP and FP24

Answer 5

• FFP: plasma frozen within 8 hours
  -> contains max lvls of clotting factors (unstable)
• FP24: plasma frozen within 24 hours
  -> contains all stable clotting factors (reduced F5 and 8)

Question 6

how is cryoprecipitate made

Answer 6

• FFP is thawed slowly at 1-6C
• the liquid is removed (cryo reduced) and the solid is resuspended in the remaining plasma (cryoprecip)

Question 7

describe cryo-reduced plasa

Answer 7

• left over plasma from making cryo
• contains plasma proteins and ADAMTS13
• best for TTP patients

Question 8

how are plasma fractions made

Answer 8

• from plasma from whole blood or apheresis
• pH/alcohol/temp separations
• viral inactivation
• stored lyophilized (longer expiration)
• used for diagnosed factor deficiencies to avoid volume overload of plasma

Question 9

describe plasma fraction: factor VII

Answer 9

• used in massive bleeding situations
• causes spontaneous thromboli

Question 10

describe plasma fraction: factor VIII

Answer 10

• used for heomophilia A treatment, replacing cryo
• safe from HIV

Question 11

describe plasma fraction: prothrombin complex

Answer 11

• contains vitamin K dependent factors (2, 7, 9, 10)
• used for massive bleeds
• may cause DIC/ thrombosis

Question 12

describe plasma fractions: FIX

Answer 12

• contains factor 9
• hemophelia B

Question 13

describe plasma fraction antithrombin III

Answer 13

• prevents trhomboembilism in surgical cases
• INHIBITS factors: 9,10, 11, 12

Question 14

true or false
vitamin K deficiency is treated with oral vitamin K, not the factors

Answer 14

true

Question 15

true or false
factors 8 and 9 are preferred medicine for diagnosed hemophilia over cryo

Answer 15

true
- cryo is used temporarily until the missing factor can be used

Question 16

describe IVIG or IMIG

Answer 16

concentrated IgG for immunocompromised/unable to form passive Ab
- IgA deficient pt may have allergic rxn

Question 17

describe rhogam

Answer 17

• IgG anti-D prevents HDF

Question 18

describe normal serum albumin NSA

Answer 18

for shock and burn patients or hypovolemic

Question 19

describe lactated ringers

Answer 19

• crstails containing Na, K, Cl, Ca and lactate
• increases volume without plasma use
• will clot if transfused with red cells

Question 20

describe dextran

Answer 20

• colloid containing sugar soln
• increase volume without plasma and no coag

Question 21

describe convalescent plasma

Answer 21

plasma from patient recently recovering from specific disease
- passive immunity

Question 22

what pretransfusion testing must be done on plasma

Answer 22

• must be reverse type matched -> Rh not a problem
• no Ab screen
• no crossmatch