Plant Alkaloids- Majority are vesicants, Mylosuppresion, Diarrhea, peripheral neuropathies

Question 1

Irinotecan/CPT11

Answer 1

anorexia, diarrhea, N&V, used for Metastatic colon or rectal cancer

Question 2

Etoposide/VP-16

Answer 2

Crystallization during infusion, hypotension, hold if Billi .5, rashTesticular, bladder, prostate, lung, stomach, and uterine, cancers. Hodgkin’s and non-Hodgkin’s lymphoma, mycosis fungoides, Kaposi’s sarcoma, Wilm’s tumor, rhabdomyosarcoma, Ewing’s sarcoma, neuroblastoma, brain tumors.
It also may be given as high-dose therapy in bone marrow transplant setting.

Question 3

Vinblastine/Velba

Answer 3

fatal if given IT, constipation . Non Hodgkin lymphoma
Hodgkin lymphoma
Testicular cancer
Choriocarcinoma
Breast cancer
Kaposi's sarcoma
Kidney cancer
Histiocytosis X

Question 4

Vinorelbine/Navelbine

Answer 4

Fatal if given IT, N&V, peripheral neuropathy. Non-small cell lung cancer
Some healthcare providers may also give this drug for breast cancer, ovarian cancer, or Hodgkin’s disease.

Question 5

Vincristine/Oncovin

Answer 5

2mg max single dose. acute leukemia, Hodgkin’s and non- Hodgkin’s lymphoma, neuroblastoma, rhabdomyosarcoma, Ewing’s sarcoma, Wilms’ tumor, multiple myeloma, chronic leukemias, thyroid cancer, brain tumors.
It is also used to treat some blood disorders.

Question 6

Docetaxel

Answer 6

Hypersensitivity, fluid retention, rash, peripheral neuropathy, No PVC tubing, N&V. Approved in treatment of breast cancer, non-small cell lung cancer, advanced stomach cancer, head and neck cancer and metastatic prostate cancer.
Also being investigated to treat small cell lung, ovarian, bladder, and pancreatic cancers, soft tissue sarcoma and melanoma.

Question 7

Paclitaxel/Taxol

Answer 7

Hypersensitivity, anaphylactic reactions, rash, peripheral neuropathy, mucositis, N/V/D. treat breast cancer, lung cancer, and ovarian cancer. It is also used to treat AIDS-related Kaposi’s sarcoma.

Question 8

Asparaginase

Answer 8

hypersensitivity reactions (emergency meds at bedside), N&V, pancreatitis. acute lymphocytic leukemia (ALL; a type of cancer of the white blood cells).

Question 9

Arsenic Trioxide/ Trisenox

Answer 9

prolonged QT interval, baseline EKG, APL acute promyelocytic leukaemia.