Antimetabolites- N/V/D, renal and liver toxicities

Question 1

Methotrexate/MTX

Answer 1

Drug should be followed with Leucovorin and hydration, pulmonary fibrosis, renal damage, diarrhea. used for breast and lung cancer

Question 2

Cytarabine/Ara-C

Answer 2

Tx for Leukemia for 7 days (7&3), allopurinol with hydration to prevent TLS

Question 3

Capecitabine/Xeloda

Answer 3

PO, take with food, monitor PT and INR if on warfarin, diarrhea, palmar-planter erythodyseasthesia. used for breast cancer and colorectal cancer.

Question 4

Fluorouracil/5FU

Answer 4

Ice chips pre and post tx, leucovorin.diarrhea, angina, radiosensitizer. Colon and rectal cancer
Anal
Breast cancer
Gastrointestinal cancers including: anal, esophageal, pancreas and gastric (stomach)
Head and neck cancer
Unknown primary (squamous cell)
Neuroendocrine tumors
Thymic cancers
Cervical cancer
Bladder cancer
Hepatobiliary cancers

Question 5

Azacitidine/Vidaza

Answer 5

Given within one of mixing, IV or SC, MDS. used for bone marrow cancer

Question 6

Nelarabine/arranon

Answer 6

neuro toxicities, seizures, somnolence. used for lymphoblastic lukemia

Question 7

Hydroxyurea/ Hydrea

Answer 7

Mucositis, CBS q 2 weeks, Flulike symptoms, skin rash, radiosensitizer.