Alkylating Agents- Cell cycle non-specific, highly emetogenic, alopecia, if oral adm. in AM

Question 1

Bendamustine /Trenda

Answer 1

Risk for TLS, skin reactions, Flu like symptoms/used for chronic lymphocytic lukemia

Question 2

Cyclophosphamide/cytoxan

Answer 2

Hydration, mesna, hemorrhagic cystitis, SIADH, N&V

used for breast cancer, lukemia and ovarian cancer

Question 3

Melphalan(I)/Alkeran

Answer 3

Pulmonary fibrosis, ice during infusion of high dose, mylosuppression 4-6 weeks after TX/ used for multiple myeloma and certain type of ovarian cancer

Question 4

Cisplatin/Platinol

Answer 4

Hold if SCr > 1.5 (renal function test), pre and post hydration, mannitol, N&V, Ototoxicity, renal damage, radiosensitizer. used for various types of cancer.

Question 5

Oxaliplatin (I with V potential)/ Eloxatin

Answer 5

Pharyngolaryngeal dysesthesia when exposed to cold, peripheral neuropathy/ used for bowel cancer, colo and rectal cancer

Question 6

Thiotepa

Answer 6

bone marrow suppression, N&V, mucositis, skin rash
Treatment of breast and ovarian cancer, and Hodgkin’s and non-Hodgkin’s lymphomas.
Treatment of superficial tumors of the bladder.
To help control the accumulation of fluid in body cavities that may result from certain cancers

Question 7

Carmustine (I)/BICNU

Answer 7

Crosses blood-brain barrier, pulmonary fibrosis, Glass bottle, NHL HL Myeloma brain. used for multiple myeloma and brain cancer

Question 8

Dacarbazine (I)/ DTIC

Answer 8

Drug light sensitive, must cover, may cause pain at injection site, N&V, melanoma Hodgkins

Question 9

Ifosfamide/ifex

Answer 9

always administer with Mesna

Question 10

Temozolomide/ Temodar

Answer 10

PO, dose limiting mylosuppression, avoid sun exposure, take on empty stomach. used for brain cancer

Question 11

Carboplatin/paraplatin

Answer 11

Drug light sensitive, AUC dosing, N&V, Hypersensitivity reactions, late dose hypersensitivity. used for small cell lung cancer and ovarian cancer